检测肝癌微转移的研究新进展

原发性肝癌是全球高发病率的恶性肿瘤之一。手术切除是治疗原发性肝癌的首选手段, 然而手术切除后复发率、转移率高, 预后差是严重制约手术治疗远期疗效的重要因素。肝癌的转移是一个多步骤、多因素相互作用的复杂过程。近年来研究发现微转移是引起肿瘤复发和转移的根源, 微转移的检测对肿瘤的准确分期、指导治疗、判断预后有重要意义, 目前常用肝癌微转移灶检测标志物包括端粒酶、甲胎蛋白mRNA、MicroRNAs、上皮型钙黏素、CD44v6 mRNA和细胞角蛋白。本文从肝癌微转移灶的概念背景、标本来源、检测标志物、检测方法及相关临床意义等方面对肝癌微转移的研究进展进行综述, 旨在探讨微转移灶检测在肝癌临床治疗及预后中的重要意义。 

Research progress on micrometastasis of hepatocellular carcinoma

Primary liver cancer(PLC) is a malignant tumor with a very high incidence worldwide.Surgery is commonly the treatment of choice for PLC.However, tumor recurrence and metastasis after surgery seriously hamper the long-term efficacy of surgical treatment.The metastasis of hepatocellular carcinoma has long been known to involve a multi-step treatment process.Recent studies have shown that micrometastasis is the cause of tumor recurrence and metastasis.The detection of micrometastasis facilitates the accurate staging of the tumor, treatment, and prognosis.At this writing, markers for detecting liver cancer micrometastasis are available, including telomerase, al pha-fetoprotein mRNA, micro RNAs, E-cadherin, CD44v6mRNA, and cytokeratin.In this study, the researchers reviewed the research progress on the micrometastasis of liver cancer by examining the concept, source of specimen, detection methods, and clinical pathology to investigate the significance of each in the treatment and prognosis of the cancer.