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Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics |
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| Authors: | Boris Klempa Tatjana Avsic-Zupanc Jan Clement Tamara K. Dzagurova Heikki Henttonen Paul Heyman Ferenc Jakab Detlev H. Kruger Piet Maes Anna Papa Evgeniy A. Tkachenko Rainer G. Ulrich Olli Vapalahti Antti Vaheri |
| Affiliation: | 1. Institute of Virology, Helmut-Ruska-Haus, Charité Medical School, Berlin, Germany 2. Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia 3. Institute of Microbiology and Immunology, Ljubljana, Slovenia 4. National Belgian Reference Laboratory for Hantavirus Infections, Rega Institute, Katholieke Universiteit, Leuven, Belgium 5. Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow, Russia 6. Finnish Forest Research Institute, PL 18, 01301, Vantaa, Finland 7. Research Laboratory for Vector Borne Diseases, Queen Astrid Military Hospital, Brussels, Belgium 8. Virological Research Group, Szentágothai János Research Center, University of Pécs, Pécs, Hungary 9. Faculty of Sciences, Institute of Biology, University of Pécs, Pécs, Hungary 10. Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece 11. Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany 12. Department of Virology, Infection Biology Research Program, Haartman Institute, University of Helsinki, PL 21, 00014, Helsinki, Finland |
| Abstract: | Dobrava-Belgrade virus (DOBV) is a human pathogen that has evolved in, and is hosted by, mice of several species of the genus Apodemus. We propose a subdivision of the species Dobrava-Belgrade virus into four related genotypes – Dobrava, Kurkino, Saaremaa, and Sochi – that show characteristic differences in their phylogeny, specific host reservoirs, geographical distribution, and pathogenicity for humans. |
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