血管内皮生长因子和钙粘合素在非小细胞肺癌中的表达及临床意义

目的 探讨血管内皮生长因子（VEGF）和上皮钙粘合素（E－cd)在非小细胞肺癌（NSCLC）中的表达水平及癌细胞发生侵袭、转移过程中的意义。方法 采用超敏过氧化酶免疫组织化学法检测手术切除的43例NSCLC组织标本中VEGF和E－cd的表达水平。结果 VEGF在高分化和中低分化组的阳性表达率分别为60.0%和86.9%，E－cd在高分化和中低分化组的阳性表达率分别为65.0%和34.9%，伴有与不伴有癌旁转移的NSCLC病例间其VEGF和E－cd阳性表达水平差异均有显著性意义。结论 VEGF和E－cd的表达水平与NSCLC侵袭、转移密切相关。

Significance and expression of vascular endothelial growth factor and E-cadherin in non-small cell lung Carcinomas

Objectives To study the expression of vascular endothelial growth factor (VEGF) and E cadherin (E cd) in non small cell lung carcinomas (NSCLC) and explore the mechanism of invasion and metastasis of tumor cell. Method The expression of VEGF and E cd was analyzed in surgical specimens (43 cases of NSCLC) by SP immunohistochemical method. Results The positive rates of VEGF in the case of good differentiation and poor middle differentiation were 60 0% and 86 9% respectively,and those of E cd were 65 0% and 34 9%. The expression of VEGF and E cd in the case of metastasis was significantly different from that in the case without metastasis. Conclusion The expression of VEGF and E cd is correlated well with invasion and metastasis of NSCLC.