| 心肌局部缺血的预适应 |
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| 引用本文： | Tyagi P,Tayal G. 心肌局部缺血的预适应[J]. Acta pharmacologica Sinica, 2002, 23(10): 865-870 |
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| 作者姓名： | Tyagi P Tayal G |
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| 作者单位： | Department of Pharmacology,Maulana Azad Medical College,New Delehi 110002,India,Department of Pharmacology,Maulana Azad Medical College,New Delehi 110002,India |
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| 摘 要： | Preconditioning of the myocardium with short episodes of sublethal ischemia will delay the onset of necrosis during a subsequent lethal ischemic insult. Ischemic preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-acti-vated protein kinases, opening of ATP-sensitive potassium channel, and expression of many protective proteins. The purpose of this review is to assess the current position in this field and to facilitate future research.
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| 关 键 词： | 局部缺血预处理 腺苷 线粒体 一氧化氮 心肌 |
Ischemic preconditioning of myocardium |
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| Tyagi Priya,Tayal Girish. Ischemic preconditioning of myocardium[J]. Acta pharmacologica Sinica, 2002, 23(10): 865-870 |
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| Authors: | Tyagi Priya Tayal Girish |
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| Affiliation: | Department of Pharmacology, Maulana Azad Medical College, New Delehi 110002, India. priyatyagi@hotmail.com |
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| Abstract: | Preconditioning of the myocardium with short episodes of sublethal ischemia will delay the onset of necrosis during a subsequent lethal ischemic insult. Ischemic preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-acti-vated protein kinases, opening of ATP-sensitive potassium channel, and expression of many protective proteins. The purpose of this review is to assess the current position in this field and to facilitate future research. |
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| Keywords: | ischemic preconditioning adenosine mitochondria nitric oxide myocardium |
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