麦迪霉素的抗菌活性

麦迪霉素是1974年从我国土壤中分离的链霉菌(Streptomyces Sp.)1748所产生的抗菌素。根据理化性质的研究证实与日本的麦地加霉素(Mydecamycin)相同。本文通过体内外抗菌活性的研究证明麦迪霉素对金黄色葡萄球菌、链球菌和肺炎双球菌等革兰氏阳性菌具有较强的抗菌作用,最低抑菌浓度为0.19～3.12μg/ml。诱导耐药实验证实麦迪霉素属于非诱导型抗菌素。在实验治疗的比较试验中证明麦迪霉素对小白鼠感染金黄色葡萄球菌、溶血性链球菌和肺炎双球菌的治疗效果与日本的麦地加霉素相同或优于后者。

THE ANTI-MICROBIAL ACTIVITIES OF MAIDIMEISU

Maidimeisu is a macrolide antibiotic produced by Streptomyces sp. 1748 isolated from Chinese soil. A study of its chernical structure showed that it is identical to mydecamycin reported in Japan. The antimicrobial activities of maidimeisu were studied in vitro and in vivo.Maidimeisu exhibited strong antimicrobial activity against gram-positive bacteria.The minimal inhibitory concentration (MIC)of maidimeisu ranged from 0.19 to 3.125 μg/ml.Contact of Staphylococcus aureus 902—56, a clinical isolate, with subinhibitory concentration of maidimeisu did not induce resistance to the same antibiotic. Hence, contrary to erythromycin, maidimeisu belongs to the non-inductive type of macrolides.Treatment of mice with staphylococcal, streptococcal and pnemococcal infections showed that maidimeisu is similar to the Japanese medecamycin.