芪苓柴虎汤治疗慢性乙型肝炎的临床研究

目的:探讨中药芪苓柴虎汤(QLCHS)对慢性乙型肝炎的疗效。方法:设QLCHS治疗组、干扰素组和常规护肝组以比较其抗乙肝病毒(HBV)及降酶作用。结果:经卡方检验,QLCHS组HBeAg转阴率为56.5％,HBVDNA转阴率为33.3％,均显著高于常规护肝组(分别为9.3％和11.1％),差异显著(P<0.01);QLCHS组的HBeAg和HBV DNA转阴率则与干扰素组无显著差异(P>0.05)。各组丙氨酸转氨酶(ALT)依次有76.8％、82.5％和61.1％恢复正常水平,无显著差异(P>0.05)。结论:QLCHS对慢性乙型肝炎病人HBeAg、HBV DNA的转阴有明显的疗效,并有一定的降ALT作用;有希望作为治疗慢性乙型肝炎的专病专方。

Clinical Study of Qiling Chaihu Solution for Chronic Hepatitis B Patients

Objective: To investigate the curative effect of traditional Chinese medicine Qiling Chaihu Solution (QLCHS) for chronic hepatitis B (CHB). Methods: Using QLCHS to resist HBV and decreasing enzyeme by clinical experiment group QLCHS, group IFN, and group of routine protecting liver group were set up to compare the effect. The HBsAg was detected by SP-RIA, HBeAg was detected by ELISA, and the HBV DNA was detected by PCR. Results: According to x2 check, the turning negative rate of HBeAg and HBV DNA in group QLCHS (56.5 % and 33.3 % ) was obviously higher than that of the group of troutine protecting liver (9.3% and 11.1%) (P<0.01), while it were not distinctive, between group QLCHS and group IFN. The serum ALT activity has recovered to the normal level in the three groups were 76.8 % , 82.5 % and 61.1% respectively. It was not distinctive among the three groups (P>0.05). Conclusion: QLCHS has tangible curative effect for turning negative of HBeAg and HBV DNA in CHB patients, and it is active to decrease the level of ALT, which has been certified by clinical experience. So QLCHS can be regarded as the special prescribe for CHB.