Anemia in beta-thalassemia patients targets hepatic hepcidin transcript levels independently of iron metabolism genes controlling hepcidin expression |
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Authors: | Camberlein Emilie Zanninelli Giuliana Détivaud Lénaïck Lizzi Anna Rita Sorrentino Francesco Vacquer Stefania Troadec Marie-Bérengère Angelucci Emanuele Abgueguen Emmanuelle Loréal Olivier Cianciulli Paolo Lai Maria Eliana Brissot Pierre |
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Affiliation: | Inserm U-522, IFR 140, University Hospital Pontchaillou, Rennes, France. |
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Abstract: | Thalassemia associates anemia and iron overload, two opposite stimuli regulating hepcidin gene expression. We characterized hepatic hepcidin expression in 10 thalassemia major and 13 thalassemia intermedia patients. Hepcidin mRNA levels were decreased in the thalassemia intermedia group which presented both lower hemoglobin and higher plasma soluble transferrin receptor levels. There was no relationship between hepcidin mRNA levels and those of genes controlling iron metabolism, including HFE, hemojuvelin, transferrin receptor-2 and ferroportin. These results underline the role of erythropoietic activity on hepcidin decrease in thalassemic patients and suggest that mRNA modulations of other studied genes do not have a significant impact. |
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