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| 均匀设计对眼镜蛇神经毒素与咖啡因配伍优化研究 | |
| 引用本文： | 黄铭,郝永龙,陈美荣,俞丽霞. 均匀设计对眼镜蛇神经毒素与咖啡因配伍优化研究[J]. 中华中医药学刊, 2007, 25(9): 1960-1961 |
| 作者姓名： | 黄铭 郝永龙 陈美荣 俞丽霞 |
| 作者单位： | 1. 山东中医药大学第二附属医院,山东,济南,250011 2. 山东中医药大学附属医院,山东,济南,250011 3. 浙江中医药大学,浙江,杭州,310053 |
| 摘 要： | 采用均匀设计，研究眼镜蛇神经毒素（α-Cobrotoxin）与咖啡因的组方，寻找其最佳配伍。结果表明眼镜蛇神经毒素起主要镇痛作用，咖啡因具有协同镇痛作用，为咖啡因用于镇痛提供实验依据。 |
| 关 键 词： | 眼镜蛇神经毒素 咖啡因 镇痛 均匀设计 |
| 文章编号： | 1673-7717（2007）09-1960-02 |
| 收稿时间： | 2007-04-14 |
| 修稿时间： | 2007-04-14 |
Study on Optimized Fromula of Caffeine and Chinse Cobraneurotoxin by Well-distribute Design |
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| HUANG Ming,HAO Yong-long,CHENG Mei-rong,YU Li-xia. Study on Optimized Fromula of Caffeine and Chinse Cobraneurotoxin by Well-distribute Design[J]. Chinese Archives of Traditional Chinese Medicine, 2007, 25(9): 1960-1961 | |
| Authors: | HUANG Ming HAO Yong-long CHENG Mei-rong YU Li-xia |
| Affiliation: | 1. Second Affiliated Hospital of Shandong University of TCM, Jinan 250001, Shandong, China ; 2. Affiliated Hospital of Shandong University of TCM, Jinan 250011, Shandong, China; 3. Zhejiang University of TC M, Hangzhou 310053, Zhejiang, China |
| Abstract: | To reseach the ratio of Chinese cobraneurotoxin and caffeine in optimized formula by well- distribute design. Results showed Chinese cobraneurotoxin played the main role in analgesia, caffeine had the synergistic analgesic effect . The research provided the experimental basis of caffeine applied in drug with analgesia . |
| Keywords: | chines cobraneurotoxln caffeine analgesia well - distributed design |
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