胎盘蛋白激素类物质在胎盘组织及母血清中分泌的动态观察

本文应用放射免疫法对妊娠早、中、晚期的胎盘组织及血清申SP_1,hPL和hCG水平进行了测定,并对孕晚期异常妊娠进行了观察。结果表明,胎盘组织和母血清的hCG水平随孕周增加而逐渐降低。而SP_1和hPL含量则随孕周的增加而逐渐增加。在孕晚期胎盘组织和母血清中的SP_1,hPL和hCG存在明显的正相关性。妊高征和IUGR孕妇血清SP_1值明显低于正常妊娠组(P<0. 01),正常妊娠和异常妊娠胎盘组织的SP_1含量无明显差异(P>0. 05)。我们认为测定孕妇血SP_1、hPL和hCG值均可反映胎盘整体的功能状态,作为判定胎盘功能,监护高危妊娠的方法。

Dynamic observation of placental proteic hormone secretions in placental tissue, maternal serum

Placental and serum levels of pregnancy - specific beta 1 - glycoprotein (SP1), human placental lactogen (hPL) and human chorionic gonadotropin (hCG) in early, middle and late pregnancies were measured with radioimmuno-assay, and observed for abnormal pregnancies in late pregnancy. The results indicated that hCG levels of placental tissue and serum decreased, while SP1 and hPL levels increased with the number of gestation weeks. A positive correlation existed between SP1, hPL and hCG levels in placental tissue and maternal serum. Maternal serum SP1 levels in toxemia and IUGR were lower than those in normal pregancy (P<[0.001), and there was no significant difference (P>05) between SP1 levels of normal and abnormal placental tissues. It is concluded that serum SP1, hPL and hCG level measurement reflects functional condition of placenta , and can be used as a method for monitoring high-risk pregnancies.