| 辛硫磷对大鼠精子生成量和精子运动能力的影响 |
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| 引用本文： | 詹宁育,王沭沂,王心如.辛硫磷对大鼠精子生成量和精子运动能力的影响[J].卫生研究,2000,29(1):4-6. |
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| 作者姓名： | 詹宁育 王沭沂 王心如 |
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| 作者单位： | 南京医科大学毒理研究所!南京210029 |
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| 基金项目： | “九五”国家重点科技攻关项目基金!(No.96-906-04-11)，国家自然科学基金!(No.39640006) |
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| 摘 要： | 为探讨有机磷杀虫剂辛硫的雄性生殖毒性，运用动物实验研究了不同剂量辛硫磷径口染毒大鼠６０天对精子生成量和精子运动能力的影响。采用计算机辅助精子分析仪分析精了轨迹。结果显示：辛硫磷２４．５和７３．５ｍｇ／ｋｂＢＷ染毒组，大鼠睾丸精子生成量低于对照组。
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| 关 键 词： | 辛硫磷 精子生成量 精子运动能力 农药 生殖毒性 |
Effects of phoxim on sperm production and motility of rats |
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| Zhan Ningyu,Wang Shuyi,Wang Xinru.Effects of phoxim on sperm production and motility of rats[J].Journal of Hygiene Research,2000,29(1):4-6. |
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| Authors: | Zhan Ningyu Wang Shuyi Wang Xinru |
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| Institution: | Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China. |
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| Abstract: | The effects of phoxim at various dosage levels on sperm production and motility in rats were studied. Sperm motility was measured by computer assisted sperm analysis (CASA). The results showed that rats exposed to phoxim at higher doses(24.5 and 73.5 mg/kgBW) for 60 successive days showed significant reduction of daily sperm production as compared with the control (P < 0.05, P < 0.01). Sperm motion parameters such as currilinear velocity (VCL), straight line velocity(VSL), beat cross frequency(BCF), linearity(LIN) and straightness(STR) were significantly decreased than those of the control(P < 0.05, P < 0.01) which indicated a dose-dependent relationship to some extent. However, there was no obvious change in body weight, testis weight and the rate of motile sperm in epididymis. It suggests that the male reproductive toxicilIty of phoxim at higher doses (24.5 and 73.5 mg/kgBW) mainly induces a reduction of sperm production and motility. |
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| Keywords: | phoxim sperm production sperm motility compater assisted sperm analysis |
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