| 典型醛类污染物单独及联合作用对小鼠脾淋巴细胞DNA损伤的离体实验研究 |
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| 引用本文： | 杨丹凤,袭著革,张华山,李官贤,梁增辉.典型醛类污染物单独及联合作用对小鼠脾淋巴细胞DNA损伤的离体实验研究[J].卫生研究,2000,29(1). |
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| 作者姓名： | 杨丹凤 袭著革 张华山 李官贤 梁增辉 |
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| 作者单位： | 军事医学科学院卫生学环境医学研究所,天津,300050 |
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| 摘 要： | 应用单细胞凝胶电泳技术(彗星实验)检测了3种典型醛类污染物对小鼠脾淋巴细胞DNA损伤情况。结果发现3种化合物都引起了小鼠脾淋巴细胞产生彗星现象,并且存在一定的剂量-效应关系。表明此3种醛类化合物均可引起细胞DNA发生断裂
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| 关 键 词： | 甲醛 乙醛 丙烯醛 DNA损伤 |
Effect of typical aldehyde pollutants on the DNA damage of spleen lymphocytes of mice |
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| Yang Danfeng,Xi Zhuge,Zhang Huashan,Li Guanxian,et al..Effect of typical aldehyde pollutants on the DNA damage of spleen lymphocytes of mice[J].Journal of Hygiene Research,2000,29(1). |
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| Authors: | Yang Danfeng Xi Zhuge Zhang Huashan Li Guanxian |
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| Institution: | Yang Danfeng,Xi Zhuge,Zhang Huashan,Li Guanxian,et al. Institute of Environmental Medicine,Academy of Military Medical Sciences,Tianjin 300050,China |
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| Abstract: | The DNA damage of spleen lymphocytes induced by three typical aldehyde pollutants was studied in vitro with microgel single cell electrophoresis assay (comet assay).It showed that the comet cells induced by the three chemicals were observed,and the dose dependent relations were existed.It suggested that the three aldehydes could induce DNA strand breakage. |
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| Keywords: | formaldehyde acetaldehyde acrolein DNA damage |
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