TNT作业工人尿中TNT及其代谢物含量的研究

寻找职业接触ＴＮＴ敏感、特异的生物监测指标及制订生物接触限值（ＢＥＬ）。方法对车间空气中ＴＮＴ浓度与接触者尿中ＴＮＴ、代谢物４氨基２，６二硝基甲苯（４Ａ）和２氨基４，６二硝基甲苯（２Ａ）含量的相关性进行了分析。结果尿中ＴＮＴ及其代谢物含量与空气中ＴＮＴ浓度显著相关，尤其是４Ａ和２Ａ。班后与班前比较，尿中４Ａ含量班后显著高于班前。结论班后尿中４Ａ含量是职业接触ＴＮＴ生物监测的敏感指标。

Studies on Urine Concentrations of TNT and Its Metabolite

Objective To look for a sensitive and specific indicator reflecting exposure to TNT for biological monitoring and to formulate a biological exposure limit of TNT.Methods Relationship between air concentrations of trinitrotoluene(TNT)at workplaces,urine levels of TNT,4 amino 2,6 dinitrotoluene(4A)and 2 amino 4,6 dinitrotoluene(2A),metabolite of TNT,in the exposed workers was analyzed.Results Urine levels of TNT and its metabolite correlated significantly to air concentrations of TNT at workplaces,especially 4A and 2A.Urine levels of 4A were significantly higher before than after work shifts.Conclusion It suggests that urine level of 4A after work shift is a sensitive indicator for occupational exposure to TNT.