| 双叶抗栓素抗血栓形成作用的研究 |
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| 引用本文： | 刘泽霖,谭获,刘敏涓,冯莹,关东文,张薇. 双叶抗栓素抗血栓形成作用的研究[J]. 血栓与止血学, 1994, 0(1) |
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| 作者姓名： | 刘泽霖 谭获 刘敏涓 冯莹 关东文 张薇 |
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| 作者单位： | 广州医学院附属二院、血液学研究室，广州医学院附属二院、血液学研究室，广州医学院附属二院、血液学研究室，广州医学院附属二院、血液学研究室，广州医学院附属二院、血液学研究室，广州医学院附属二院、血液学研究室 广州 510260，广州 510260，广州 510260，广州 510260，广州 510260，广州 510260 |
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| 摘 要： | 本文报道了五叶参、桑叶抗血栓形成的新作用。通过体外实验研究证实,五叶参、桑叶水煮制备液能明显抑制ADP、复合诱聚剂诱导的血小板1分、5分、最大聚集率,并促进解聚发生(P均<0.05):二种药物还对体外血栓形成具有显著的抑制作用(P均<0.05;五叶参、桑叶与PPP混合后,尚能抑制多种凝血因子活性.使KPTT、PT、TT、AT、RVV-RT、RVV-CT等凝血试验时间延长(P均<0.05);此外.二种药物皆可加速红细胞电泳速度。上述结果表明,五叶参、桑叶是二种具有抑制血小板功能、凝血象及红细胞聚集性等多个环节的抗血栓形成药物,值得进一步研究探讨。
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| 关 键 词： | 五叶参 桑叶 血栓 |
Study on Antithrombotic Effect Shuang Xie Kang Shuan Su |
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| Liu Ze-lin,Tan Huo,Liu Min-juan,et al. Study on Antithrombotic Effect Shuang Xie Kang Shuan Su[J]. Chinese Journal of Thrombosis and Hemostasis, 1994, 0(1) |
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| Authors: | Liu Ze-lin Tan Huo Liu Min-juan et al |
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| Abstract: | Human blood samples were investigated in vitro to observe the antithrombotic effect of water extract of Gy-nostemma pentaphyllum and Moms alba L, these two kinds of Chiness herb medicines are called Shuan Xie Kang Shuan Su, (SXKSS). The results showed that SXKSS could inhibit significantly the platelet aggregation induced by ADP and compound agonists (P<0. 05) , accelerate obviously the disaggregation (P<0. 05) and inhibit effectively the experimental thrombosis (P<0. 05). The delayed effects of SXKSS on KPTT, PT, TT, AT, RVV-RT, RVV-CT suggested that these drugs could decrease the activity of multiple coagulation factors. And it showed that SXKSS could accelerate the ery-throcyte electrophoresis rate. This study revealed that Gynostemma pentaphyllum and Morus abla L are two kinds of antithrombotic agents affecting the links of thrombotic chain which are worthwhile to be studied further. |
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| Keywords: | Gynostemma pentaphyllum Morus alba L. Shuang Xie Kang Shuan Su (SXKSS) thrombosis coagula-tive function erythrocyte electrophoresis |
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