叶下珠中新多酚化合物的分离与鉴定

目的:研究植物药叶下珠(Phylanthus urinaria L.)的化学成分。方法:用各种色谱技术进行分离纯化,经MS,¹H,¹³CNMR和HMBC光谱分析鉴定其结构。结果:分得4个多酚类化合物,其结构分别鉴定为1-O-没食子酰基 3,6-六羟基联苯二甲酰基-2,4-去羟甲基诃子酰基-吡喃葡糖(I),焦棓酚(pyrogalol,I),咖啡酸(cafeicacid,II)和(brevifolincarboxylic acid,IV)。结论:化合物I为一新的鞣花单宁(命名为phylanthusinU),I,II,IV为首次从该植物中分得。

ISOLATION AND IDENTIFICATION OF A NOVEL POLYPHENOLIC COMPOUND FROM PHYLLANTHUS URINARIA

AIM: To study the chemical constituents the medicinal plant Phyllanthus urinaria L. METHODS: The constituents were separated and purified by using various chromatographies. The structural elucidation of the compounds were based on the analysis of their MS,¹H & ¹³CNMR and HMBC spectra. RESULTS: Four polyphenolic compounds were obtained from P.urinaria and their structures were identified as: 1-O-galloyl-3,6-O-0HHDP-2,4-O-dehydroxymethyl chebuloyl-βD-glucopyranose (I), pyrogallol (II), caffeic acid (III) and brevifolincarboxylic acid (IV). CONCLUSION: Compound I was found to be a novel ellagitannin, named phyllanthusiin U, and II～IV were isolated from this plant for the first time.