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急性脑梗死患者血浆溶血磷脂酸水平的变化及其意义
引用本文:王志晔,张作念,顾伟,潘振华,朱诚,潘锡近. 急性脑梗死患者血浆溶血磷脂酸水平的变化及其意义[J]. 中国医药, 2010, 5(2): 117-118. DOI: 10.3760/cma.j.issn.1673-4777.2010.02.009
作者姓名:王志晔  张作念  顾伟  潘振华  朱诚  潘锡近
作者单位:1. 上海梅山医院神经科,南京,210039
2. 上海梅山医院检验科,南京,210039
3. 南京大学附属鼓楼医院神经科
摘    要:目的探讨急性脑梗死患者血浆溶血磷脂酸(LPA)水平变化及其临床意义。方法应用有机溶剂抽提法对67例急性脑梗死患者(急性脑梗死组)动态检测血浆LPA含量,分析其与梗死部位(皮质支和深穿支)的关系,并与40例健康体检者(正常对照组)进行对照。结果急性脑梗死组发病后6h血浆LPA含量[(3.45±0.32)μmol/L]明显高于正常对照组[(2.63±0.31)μmol/L,P〈0.01],并在发病后24h达到高峰[(4.05±0.51)μmol/L],14d接近正常,与高峰点比较差异有统计学意义(P〈0.01);皮质支组发病后24h血浆LPA水平[(4.64±0.55)μmol/L]高于深穿支组(P〈0.01)。结论急性脑梗死患者血浆LPA水平与病程、病灶部位有关。LPA在急性脑梗死发生时具有预警作用,对急性脑梗死的防治具有重要的临床意义。

关 键 词:急性脑梗死  血浆溶血磷脂酸

Change of plasma lysophosphatidic acid in patients with acute cerebral infarction
WANG Zhi-ye,ZHANG Zuo-nian,GU Wei,PAN Zhen-hua,ZHU Cheng,PAN Xi-jin. Change of plasma lysophosphatidic acid in patients with acute cerebral infarction[J]. China Medicine, 2010, 5(2): 117-118. DOI: 10.3760/cma.j.issn.1673-4777.2010.02.009
Authors:WANG Zhi-ye  ZHANG Zuo-nian  GU Wei  PAN Zhen-hua  ZHU Cheng  PAN Xi-jin
Affiliation:WANG Zhi-ye, ZHANC Zuo-nian, GU Wei, PAN Zhen-hua, ZHU Cheng, PAN Xi-fin. (Department of Neurology, Shanghai Meishan Hospital, Nanjing 210039, China)
Abstract:Objective To investigate the changes and the significance of plasma lysophosphalidic acid (LPA) in patients with acute cerebral infarction(ACI). Methods The levels of plasma LPA were examined with organic solvent extraction in 67 cases of ACI and 40 cases of health examination (control group). The correlation between the levels of plasma LPA and the infarction sites was analyzed. Results The level of plasma LPA were higher in cases with ACI than those in healthy controls(P <0.01) and it reached the peak after 24 hours and went back to the normal level on the 14th day (P <0.01). The level of LPA in cortical branches was higher than that in deep branches(P <0.01). Conclusions The level of LPA in cases with ACI was related to the course of disease and the site of infarction. LPA showes the prewarning effect when the acute cerebral infarction occured. LPA has im-portant clinical significance of preventing and treating the acute cerebral infarction.
Keywords:Acute cerebral infarction  Plasma lysophosphatidic acid
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