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Parkinson's disease: depletion of substantia nigra neurotensin receptors |
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| Authors: | G.R. Uhl P.J. Whitehouse D.L. Price W.W. Tourtelotte M.J. Kuhar |
| Abstract: | Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. ‘Saturation’ analysis suggests that these changes result from receptor loss. These results support a neurotensin-domapine interaction in human nigro-striatal circuits. |
| Keywords: | Parkinson's disease neurotensin peptide receptor autoradiography substantia nigra |
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