Comparison between continuous and intermittent administration of Estracyt in the treatment of carcinoma of the prostate |
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| Authors: | W Vahlensieck G Wegner H D Lehmann G Franzen L Steffens S Wählby |
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| Institution: | (1) Department of Urology, University Hospital, Bonn, FRG;(2) Cologne, Holweide Hospital, Cologne, FRG;(3) St. Antonius-Hospital, Eschweiler, FRG;(4) Medical Department, Research Laboratories, AB Leo, Helsingborg, Sweden |
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| Abstract: | Summary Ninety-five patients with prostatic carcinoma, stages A-D and of all histological grades were randomized between a continuous and an intermittent treatment regimen of EstracytR (estramustine phosphate). 77 patients were evaluated (46 with continuous and 31 with intermittent therapy). Remissions were seen in 13 (28%) and (13%), respectively. Stable disease was recorded in 30 (65%) and 24 (77%), respectively. Progression experienced 3 (6%) and 3 (10%) respectively. 19% were unable to continue therapy due to intolerable gastrointestinal side effects (7 patients receiving continuous and 8 patients receiving intermittent therapy). |
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| Keywords: | Prostatic cancer Estracyt continous vs intermittent administration Therapeutic effect Side effects |
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