心脑宁胶囊治疗血管性轻度认知功能障碍的疗效观察

目的：观察心脑宁胶囊治疗血管性轻度认知障碍（vascular cognitive impairment no dementia, VCIND）的临床疗效。方法选择80例VCIND患者，随机分为治疗组和对照组，每组40例。治疗组给予口服心脑宁胶囊，对照组给予口服尼莫地平片。采用简易智能精神状态检查量表（mini-mental state examination, MMSE）和蒙特利尔认知评估（montreal cognitive assessment, MoCA）等，观察患者的认知功能变化情况，并观察相关安全性指标。结果治疗组总有效率62.5%，对照组总有效率57.9%，有统计学意义（P<0.05）；MMSE评分结果显示，治疗组疗后优于疗前（25.98±0.92 vs.24.65±0.80，P<0.01）；对照组疗后优于疗前（25.53±1.27 vs.24.87±0.91，P<0.01）；MoCA评分结果显示，治疗组疗后评分优于疗前（24.93±0.97 vs.23.28±0.96，P<0.01），对照组疗后评分优于疗前（24.53±1.03 vs.23.11±0.76，P<0.01）；两组治疗后MMSE评分比较，治疗组优于对照组（25.98±0.92 vs.25.53±1.27，P<0.05）；两组治疗后MoCA评分比较，治疗组与对照组无显著差异（24.93±0.97 vs.24.53±1.03，P>0.05）。结论心脑宁胶囊对VCIND患者的认知障碍有较好的改善作用，无明显不良反应。

Curative effect of Xinnaoning capsule-on the treatment of mild vascular cognitive impairment no dementia

Objective To evaluate the clinical curative effect of Xinnaoning Capsule on vascular cognitive impair-ment no dementia. Methods In this study, 80 cases of VCIND were divided randomly into two groups including 40 cases in the trial group and 40 cases in the control group. Patients of the trial group were given the Xinnaoning Capsule (3 tablets, tid), while those in the control group were given Nimodipine Tablets (1 tablet, tid). All patients of the two groups were treated for 6 months. A comparison of the therapeutic effect was made between both groups before and after treat-ment by mini-mental state examination (MMSE) and Montreal cognitive assessment scale (MoCA). Results There was significant difference between the total effect of the two groups (P< 0.05). The scores of MMSE were all improved after treatment in the treatment group and the control group (25.98 ±0.92 vs. 24.65 ±0.80, 25.53 ±1.27 vs. 24.87 ±0.91; all P<0.01). The scores of MoCA were all improved after treatment in the treatment group and the control group (24.93 ±0.97 vs. 23.28±0.96, 24.53±1.03 vs. 23.11±0.76; all P< 0.01), too. And the improvement of MMSE in the treatment group was superior to that in the control group (25.98 ±0.92 vs. 25.53 ±1.27; P< 0.05). Conclusion The results suggest that the Xinnaoning Capsule is effective on improving congnitive function in patients with VCIND.