0.025%醋酸地塞米松乳膏联合肤乐霜治疗婴幼儿湿疹、特应性皮炎的随机对照研究

目的：观察0.025％醋酸地塞米松乳膏联合肤乐霜治疗婴幼儿湿疹和特应性皮炎的临床疗效及安全性。方法采用随机对照法，入选患儿分为3组，A组外用0.025%醋酸地塞米松乳膏每日2次，B组外用肤乐霜每日2次，C组外用0.025%醋酸地塞米松乳膏和肤乐霜每日各1次，均共治疗2周。采用SCORAD评分对受试者的病情严重程度进行评估。结果本研究最终入选并完成试验210例，A组69例，B组71例，C组70例；3组患儿性别、年龄、疾病类型及试验前SCORAD评分的差异均无统计学意义。治疗结束时，A组的临床总有效率为83％（57/69），B组为65％（46/71），C组为84%（59/70），3组比较差异有统计学意义（P<0.01）；两两比较，A组和C组的疗效差异无统计学意义，均好于B组。3组均未见药物相关的不良反应。结论0.025％醋酸地塞米松乳膏联合肤乐霜治疗婴幼儿湿疹和特应性皮炎疗效可靠，安全性高。

Combined treatment with 0.025%dexamethasone acetate cream and Fuleshuang in infants with eczema and atopic dermatitis:a randomized controlled study

Objective To evaluate the efficiacy and safety of 0.025% dexamethasone acetate cream combined with Fuleshuang cream in infantile eczema and atopic dermatitis. Methods A randomized controlled study was conducted. Sixty-nine patients in group A were treated with 0.025% dexamethasone acetate cream twice daily, 71 patients in group B were treated with Fuleshuang cream twice daily, 70 patients in group C were treated with 0.025% dexamethasone acetate cream combine with Fuleshuang cream once daily. All patients were treated for 2 weeks. Eczema severity was evaluated by SCORAD score. Results At the end of this 2 weeks study, the clinical effective rate of group A, B and C was 83%, 65%, 84% respectively, with a significant difference among the three groups (P< 0.01). There was no difference in the clinical effective rate of group A and C, but better than group B. No adverse effect was found related to the drug in the three groups. Conclusion 0.025% dexamethasone acetate cream combined with Fuleshuang cream is effective and safe for in-fantile patients with eczema and atopic dermatitis.