血清Asprosin水平与绝经后女性骨密度、平衡能力和骨折发生率的相关性

目的 探讨血清Asprosin(白脂素)水平与绝经后女性骨密度(bone mineral density,BMD)、平衡能力和骨折发生率的相关性.方法 回顾性分析海南医学院第一附属医院收治的164例绝经后女性骨质疏松症(osteoporosis,OP)患者的临床资料.记录患者一般临床资料以及骨折发生率、髋部骨密度、平衡...

The Correlation between serum Asprosin levels and bone mineral density, balance ability and fracture incidence in postmenopausal women

Objective To explore the correlation between serum asprosin levels and bone mineral density (BMD), balance ability and fracture incidence in postmenopausal women. Methods The clinical data of 164 postmenopausal women with osteoporosis (OP) admitted to our hospital were retrospectively analyzed. The patient''s general clinical data as well as fracture incidence, hip bone density, balance index score (BIS), front-to-front ratio (FBR), and left-right ratio (RLR) were recorded. The correlation between asprosin and BMD, BIS, FBR, RLR and fracture incidence were analyzed. Results The serum asprosin level in the non- fracture group was (3.56±0.54) pg/mL, and the serum asprosin level in the fracture group was (6.56±1.01) pg/mL. There was a statistically significant difference in serum asprosin levels between the two groups (P<0.05); Spearman test results showed that asprosin was negatively correlated with BIS, FBR, RLR and BMD (P<0.05); asprosin and age (r=0.384), height (r=0.343), BMI (r=0.181) was significantly associated with hip BMD (r=0.387), but it had no significant association with body weight (r=0.022, P>0.05). Logistic regression analysis linear regression analysis showed that hip BMD, height, age and BMI were the independent factors affecting asprosin. Conclusions Asprosin may be a risk factor for postmenopausal women with reduced bone density, decreased balance, and fractures. It is closely related to hip BMD, height, age and BMI.