多穗金粟兰中1对倍半萜对映异构体的研究

目的 对多穗金粟兰Chloranthus multistachys中倍半萜类化学成分进行研究.方法 利用多种色谱方法进行分离纯化,然后利用1D-NMR、2D-NMR、单晶X射线衍射等方法进行结构鉴定.结果 从多穗金粟兰二氯甲烷部位中分离得到10个倍半萜类化合物,分别鉴定为(1R,4R,5R,8S,10R)-1-羟基-4...

A pair of sesquiterpene enantiomers from Chloranthus multistachys

Objective To study the sesquiterpenoids from Chloranthus multistachys. Methods A variety of chromatographic methods were used for the separation and purification, and then the structures were identified by 1D-NMR, 2D-NMR and Single-crystal X-ray diffraction. Results A total of 10 sesquiterpenoids were isolated from dichloromethane fraction of C. multistachys and identified as(1 R,4 R,5 R,8 S,10 R)-1-hydroxy-4-ethoxyeudesm-7(11)-en-12,8-olide(1 a),(1 S,4 S,5 S,8 R,10 S)-1-hydroxy-4-ethoxyeudesm-7(11)-en-12,8-olide(1 b),(9 S,10 S)-(-)-9β-hydroxycyclocolorenon(2), myrrhterpenoid N(3), 1α,8α,9α-trihydroxyeudesman-3(4),7(11)-dien-8β,12-olide(4), dihydrocurcolone(5), curvularin(6), neolitacumone A(7), shizukanolide F(8), and atractylenolid Ⅲ(9). Conclusion Compounds 1 a and 1 b are a new pair of sesquiterpene enantiomers, compound 2 is a new natural product, compounds 3-6 are isolated from this genus for the first time, and other compounds are isolated from this plant for the first time.