血小板及相关因子功能的异常与子宫内膜异位症发病机制的关系

子宫内膜异位症是妇科的常见病及多发病，其是一种良性的慢性疾病，影响着10%～15%的育龄女性，其症状主要表现为痛经、盆腔粘连及不孕，其发病机制已有许多的假说但尚未认识清楚。近年来国内外学者相继发现血小板在子宫内膜异位症发病中具有重要的作用，主要表现子宫内膜异位症患者的血小板黏附、聚集功能存在缺陷，子宫内膜异位症患者的血小板计数升高，其血液处于相对高凝状态，并能介导炎症反应，血小板相关因子如P-选择素、CD40L、血小板生长因子在子宫内膜异位症的发病中起到不同程度的促进作用，而且血小板能够影响子宫内膜异位症患者体内的雌激素及其受体的表达，因此综述血小板功能上的异常与子宫内膜异位症的发病机制之间可能存在的联系，为临床上应用血小板来诊治子宫内膜异位症提供理论依据。

Relationship between Platelet and Their Associated Factors with Endometriosis

Endometriosis is a common and frequently encountered disease of gynaecology, it is a kind of chronic benign disease, affecting 10% to 15% of the women of childbearing age, with main symptoms of dysmenorrhea, pelvic adhesions and infertility, but its pathogenesis has not yet known clearly, many of the hypothesis. At home and abroad in recent years, scholars have found that platelets play an important role in the incidence of endometriosis, the main performance of platelet adhesion, aggregation function in patients with endometriosis was flawed, platelet count in patients with endometriosis, its relatively high blood coagulation state, and can be mediated inflammatory response and platelet associated factors such as P-select element, CD40L, platelet growth factors in the pathogenesis of endometriosis have different degrees of promoting function, platelet can affect patients with endometriosis and the expression of estrogen and its receptors, so the review on platelet abnormal function with the pathogenesis of endometriosis may exist, for the clinical application of platelet and provide theoretical basis for treatment of endometriosis.