483例冻融胚胎移植周期妊娠结局影响因素回顾性分析

目的：探讨冻融胚胎移植（FET）周期妊娠结局的影响因素。方法：收集2016年1月-12月于中国人民解放军武汉总医院生殖医学中心行FET患者的临床资料，根据妊娠成功与否将纳入的483个周期分为妊娠组（253个周期）和非妊娠组（230个周期）。对2组一般情况进行比较，并通过Logistic回归分析探讨FET周期妊娠结局的影响因素。结果：妊娠组年龄小于非妊娠组，妊娠组移植优胚数高于非妊娠组（均P＜0.05）。Logistic回归分析显示，年龄（OR=0.715，95%CI：0.550～0.930，P=0.012）、移植优胚数（OR=1.780，95%CI：1.323～2.395，P=0.000）和胚胎类型（OR=1.737，95%CI：1.076～2.805，P=0.024）是FET周期妊娠结局的影响因素。结论：年龄越小、移植囊胚期胚胎、增加移植优胚数有利于提高FET周期种植成功率和临床妊娠率。

Retrospective Analysis of the Outcomes of Frozen Embryo Transfer in 483 Cases

Objective：To investigate the outcome and its influence factors of frozen embryo transfer (FET) cycles. Methods：A total of 483 FET cycles were retrospectively analyzed, in our Center from January to December in 2016. According to the pregnancy success or not, those cycles were divided into the pregnancy group (253 cycles) and the non-pregnancy group (230 cycles). The basic clinical data, pregnancy outcome and the influence factors between two groups were compared. Results：The mean age of the pregnancy group was significantly less than that of the non-pregnancy group, while the number of optimal embryo for FET in the pregnancy group was more (both P＜0.05). Logistic regression analysis showed that the influence factors of FET outcome included age (OR=0.715, 95%CI: 0.550-0.930, P=0.012), embryo quality (OR=1.780, 95%CI: 1.323-2.395, P=0.000) and type of embryo (OR=1.737, 95%CI: 1.076-2.805, P=0.024). Conclusions：Younger age, blastula transfer, optimal embryo transplantation were more conductive to the planting success rate and the clinical pregnancy rate of FET cycles.