侵入式柔性神经电极的植入策略

侵入式神经电极将人类对神经科学的认识提升到微米与毫秒尺度。由于传统的刚性电极与柔软的脑组织间存在较大的机械不匹配性,柔性电极成为新一代神经电极的发展趋势。神经电极的柔性化更迭降低免疫反应的同时却失去植入刚度。分析神经电极的植入机制并总结目前研究中关于柔性电极的植入策略,旨在帮助解决柔性电极的植入能力丧失以及急性植入损伤问题;并基于各种植入策略的特点,提出柔性电极植入策略的发展展望。

Implantation Strategies of Invasive Flexible Neural Electrode

Invasive neural electrodes promote human understanding of neuroscience to the micrometer and millisecond scale. Due to the large mechanical mismatch between traditional rigid electrodes and soft brain tissues, flexible electrodes have become the new trend of neural electrodes. The flexibility of the neural electrode reduces the immune response while losing the implantation stiffness. The implantation mechanism of the neural electrode was reviewed and current researches on the implantation strategies of the flexible electrodes were summarized, so as to help solve the loss of implantation ability of flexible electrode and acute implantation injury. Based on the characteristics of various implantation strategies, the prospect of flexible electrode implantation strategies was proposed.