长春西汀联合阿加曲班治疗椎基底动脉供血不足性眩晕症

目的 探讨长春西汀、阿加曲班及长春西汀联合阿加曲班在椎-基底动脉供血不足性眩晕症(VBIV)治疗中的效果.方法 选取2018年1月至2019年3月河北北方学院附属第一医院收治的VBIV病人90例,采用随机数字表法分为观察1、2、3组,每组各30例,分别给予长春西汀、阿加曲班及长春西汀联合阿加曲班治疗;使用彩色多普勒超声...

Clinical observation on vinpocetine in combined with argatroban in the treatment of vertebrobasilar insufficiency vertigo

Objective To explore the effect of vinpocetine in combined with argatroban in the treatment of vertebrobasilar insufficiency vertig (VBIV).Methods A total of 90 patients with VBIV who were admitted in the First Affiliated Hospital of Hebei NorthUniversity from January, 2018 to March, 2019 were included in the study and randomized into observation 1, 2, and 3 groups. The patients in the three groups were given vinpocetine, argatroban, and vinpocetine in combined with argatroban, respectively. The color Doppler ultrasonic diagnosis apparatus was used to detect the blood flow parameters of vertebral artery before and after treatment. The levels of superoxide dismutase (SOD) in the three groups before and after treatment were detected by hydroxylamine method. The changesof malondialdehyde (MDA) content were determined by thiobarbituric acid method (TBA method). The clinical efficacy was compared.Results The blood flow rate of the left vertebral artery, right vertebral artery, and basilar artery among the three groups before treatment was comparable (P > 0.05), while that of the above arteries after treatment was significantly enhanced (P < 0.05). The comparisonothe blood flow rate of the above arteries after treatment between observation 1 and 2 groups was not significantly different (P > 0.05),while that after treatment in observation 3 group was significantly higher than that in observation 1 and 2 groups [the left vertebral artery(38.4±4.6)cm/s vs. (31.1±4.1)cm/s and (31.5±4.1)cm/s,right vertebral artery(38.0±4.9)cm/s vs.(31.8±4.6)cm/s and (31.3±4.6)cm/s,basilar artery(38.0±4.0)cm/s vs.(32.4±4.7)cm/s and (32.5±4.1)cm/s](P < 0.05). The comparison of SOD and MDA levels before treatment among the three groups was comparable (P > 0.05), while SOD level after treatment was significantly elevated (P < 0.05), but MDA level was significantly reduced when compared with before treatment (P < 0.05). The comparison of SOD and MDA levels before treatment between observation 1 and 2 groups was not significantly different (P > 0.05), while the improvement of SOD[(73.5±12.8)U/mL vs.(56.3± 10.1)U/mL and (55.1±9.7)U/mL] and MDA[(3.5±1.1)nmol/mL vs.(4.9±1.9)nmol/mL and (4.8±1.8)nmol/mL] levels after treatment in observation 3 groups was significantly superior to that in observation 1 and 2 groups (P < 0.05). The total effective rate after one-course treatment in observation 3 groups (96.7%) was significantly higher than that in observation 1 and 2 groups (76.7% and 73.3%, respectively) (P < 0.05). The comparison of the total effective rate between observation 1 and 2 groups was not significantly different (P > 0.05).Conclusion Vinpocetine in combined with argatroban in the treatment of VBIV can rapidly relieve the clinical symptoms, andimprove the blood supply of vertebro-basilar artery, with efficacy superior to that pure adoption of vinpocetine and argatroban; therefore,it deserves to be widely recommended in the clinic.