基于CiteSpace的矿物药研究现状可视化分析

目的探索近年来矿物药研究情况、热点以及变化趋势。方法以中国知网和Web of Science为检索平台,收集有关矿物药研究的相关文献,利用可视化分析软件CiteSpace 5.1.R6通过共现网络分析的方法,对作者、国家、发文机构、关键词等内容构建知识图谱,探索分析矿物药的研究情况与前沿。结果计算机共检索、筛选获得矿物药研究相关中文文献2678篇、英文文献1454篇,中英文文献发文量总体呈波浪式上升趋势;作者群中中英文文献贡献量最多的是南京中医药大学的刘圣金和斯洛伐克科学院的Balaz;研究机构中南京中医药大学和中国科学院的中英文文献发文量最多;中英文文献的高频关键词多为单味矿物药、化学成分、药理毒理机制和临床应用等。结论近年来,中文文献的矿物药研究的热点从临床应用、本草学研究等方面,不断向其工艺、质量控制及药效物质作用机制研究方向转变;英文文献多集中于矿物药化学成分、结构性质、临床疗效、药理作用、毒副作用等方面。可见随着各学科交叉研究的加强和各种新技术及统计方法的应用,矿物药研究逐步告别起步晚、基础弱的困境,正在向标准化、现代化方向发展。

Visualization analysis of status of mineral medicine based on CiteSpace

Objective The aim of this study is to explore the research status, hotspots and changing trend of mineral drugs in recent years. Methods Based on the China national knowledge infrastructure (CNKI) and the Web of Science database platforms, articles related to mineral medicine research were collected and retrieved. Knowledge map about authors, countries, publishing organizations, keywords was constructed by using the visual analysis software CiteSpace (5.1.R6) to explore and analyze the research situation and frontiers of mineral medicine. Results A total of 2678 literatures written in Chinese and 1454 literatures written English on mineral medicine were retrieved online. In total, the trend in amount of Chinese and English literature is on the rise in waves. Scientists Sheng-jin Liu (from Nanjing University of Traditional Chinese Medicine) and Balaz Peter (from Slovak Academy of Sciences) were published the most articles in the world. For institutions, Nanjing University of Traditional Chinese Medicine and Chinese Academy of Sciences contributed the most numbers of literatures. For keywords in all articles, single-flavor mineral drugs, chemical components, pharmacological and toxicological mechanisms, and clinical applications were with relative high frequency observed in this field. Conclusion For Chinese literatures, the focus has been changing from clinical application and herbal research to the study of its technology, quality control and mechanism of pharmacodynamic substances. In contrast, English articles mostly focus on the field such as chemical constituents, structural properties, clinical effects, pharmacological effects and toxic and side effects of mineral medicine. With the application of multiple data analysis methods, multidisciplinary research has been strengthened. The prospect of mineral medicine is attracted by more scientific and interested parties. Furthermore, the study of mineral medicine is becoming standardization and modernization.