结直肠息肉危险因素及其与非酒精性脂肪性肝病相关性分析

目的探讨结直肠息肉与非酒精性脂肪性肝病（NAFLD）的相关性;分析结直肠息肉的危险因素。方法收集于我院行结肠镜检查的342例患者的临床资料,其中息肉组242例,非息肉组100例。采用卡方检验比较两组患者性别、年龄、体质指数（BMI）、NAFLD、高血压、糖尿病患病率差异;采用Mann-Whitney U检验比较两组患者血脂、肝肾功能的差异。将上述有差异的变量进行多因素Logisitic回归分析,分析结直肠息肉的危险因素。结果两组患者性别、年龄、BMI、NAFLD患病率比较差异有统计学意义（P<0.05）,而高血压、糖尿病患病率比较差异无统计学意义（P>0.05）。息肉组TG、LDL-C、GGT、ALT水平高于对照组,HDL-C水平低于对照组,差异均有统计学意义（P<0.05）,两组TC、AST、UA比较差异无统计学意义（P>0.05）。Logistic回归分析显示,男性、TG、ALT、NAFLD是结直肠息肉的危险因素。结论男性、TG、ALT、NAFLD是结直肠息肉发病的危险因素。建议男性、NAFLD患者、高脂血症等有危险因素人群定期行腹部超声及结肠镜检查。

Analysis of Colorectal Polyp Risk Factors and Their Correlation with Non-Alcoholic Fatty Liver Disease.

Objective To investigate the correlation between colorectal polyps and nonalcoholic fatty liver disease(NAFLD);Analysis of risk factors of colorectal polyps. Methods The clinical data of 342 patients who underwent enteroscopy in our hospital were collected, including polyp group(n=242)and non-polyp group(n=100). Chi-square test was used to compare the differences in gender, age, body mass index(BMI), prevalence of NAFLD, hypertension, and diabetes between the two groups of patients.The Mann-Whitney U test was used to compare the differences of blood lipid, liver and kidney function between the two groups. Multivariate Logistic regression analysis of the above variables was performed to analyze the risk factors of colorectal polyps. Results There were significant differences in sex, age, prevalence of BMI and NAFLD between the two groups, but there was no significant difference in the prevalence of hypertension and diabetes between the two groups. The levels of TG, LDL-C, GGT, and ALT in the polyp group were higher than those in the control group, and HDL-C levels were lower than those in the control group. The differences were statistically significant((P<0.05). There was no difference in TC, AST, and UA between the two groups((P<0.05). Logistic regression analysis showed that males, TG, elevated ALT, and NAFLD were risk factors of colorectal polyps.Conclusion Male, TG, ALT, NAFLD are risk factors of colorectal polyps.Regular abdominal ultrasound and colonoscopy are recommended for men, NAFLD patients, and people with risk factors such as hyperlipidemia.