肺动脉高压三尖瓣反流压差与血脑钠肽前体及并发心力衰竭的关系

目的 探讨肺动脉高压三尖瓣反流压差与血清脑钠肽前体(PRO-BNP)及并发心力衰竭的关系.方法 选取2016年2月至2018年11月无锡市精神卫生中心收治的肺动脉高压病人87例(疾病组),另选取同期体检健康者79例(健康组),均采用多普勒超声心动图检测三尖瓣反流压差及采用电化学发光法测定血清PRO-BNP水平,分析三尖...

Relationship between pro-brain natriuretic peptide and tricuspid regurgitation pressure difference in patients with pulmonary hypertension and the complicated heart failure

Objective To investigate the relationship between serum pro-brain natriuretic peptide ( PRO-BNP) and tricuspid regurgitation pressure difference in patients with pulmonary hypertension and the complicated heart failure.Methods Totally 87 patientswith pulmonary hypertension (disease group) admitted to Wuxi Mental Health Center from February 2016 to November 2018 and 79healthy persons (healthy group) undergoing health check during the same period were selected. The tricuspid regurgitation pressure differences of them were detected by Doppler echocardiography and the serum pro-brain natriuretic peptide (PRO-BNP) levels of themwere measured by electrochemiluminescence, then the relationship between tricuspid regurgitation pressure difference and serum PROBNP level was analyzed. In addition, the patients of disease group were assigned further into heart failure group and non-heart failure group according to whether they were complicated with heart failure, and the tricuspid regurgitation pressure difference and serumPRO-BNP level were compared between the two groups, and the relationships between them and heart failure were analyzed by logisticregression analysis method.Results The tricuspid regurgitation pressure difference and serum PRO-BNP level of the disease groupwere (52.17±6.58) mmHg and (619.72±113.47) ng/L respectively, higher than those of the healthy group which were (21.09±4.51)mmHg and (194.37±41.26) ng/L respectively. The differences were significant (P < 0.05). Pearson correlation analysis showed thatthere was a significant positive correlation between the tricuspid regurgitation pressure difference and the serum PRO-BNP level in the disease group (r = 0.643,P < 0.05).There were 26 cases complicated with heart failure in 87 patients with pulmonary hypertension, thecomplication rate of heart failure being 29.89% (26/57). The tricuspid regurgitation pressure difference and serum PRO-BNP level of the heart failure group were (60.15±6.23) mmHg and (698.79±115.08) ng/L respectively, higher than those of the non-heart failure