女性生殖器官血管肌纤维母细胞瘤10例诊治分析

目的：探讨女性生殖器官血管肌纤维母细胞瘤（angiomyofibroblastoma，AMF）的临床病理特点、诊治方法及预后。方法：回顾性分析2012年1月-2017年10月诊治的10例女性生殖器官AMF患者的临床资料，结合相关文献，总结其临床和病理特征、诊治方法及预后情况。结果：10例AMF患者平均发病年龄（49.90±7.62）岁，多无明显临床症状；影像学检查无特异性；镜下细胞丰富区和细胞稀疏区呈交替性分布，肿瘤组织由显著的管腔小、管壁薄和扩张的血管组成，血管周围可见嗜酸性的圆形或梭形肿瘤细胞团围绕，肿瘤基质呈疏松水肿、黏液样等，核分裂象罕见。10例患者均采取局部完整切除。术后随访8例，中位随访时间37个月，无复发。结论：发生于女性生殖器官的AMF临床表现及影像学多无特异性，诊断与鉴别诊断主要依靠病理特征及免疫组化，以手术治疗为主，预后良好。

Diagnosis and Treatment of 10 Cases of Female Genital Angiomyofibroblastoma

Objective：To investigate the clinicopathological features, diagnosis, treatment and prognosis of female genital angiomyofibroblastoma (AMF). Methods：Retrospective analysis of the clinical data of 10 female genital AMF patients treated during January 2012 to October 2017, combined with related literatures, summarized their clinical and pathological features, diagnosis, treatment and prognosis. Results：The average onset age was (49.90±7.62) years old in 10 patients with AMF. The patients had no obvious clinical symptoms, and no specificity in imaging examination. Under the microscope, the cell-rich area and cell-sparse area were alternately distributed, the tumor tissue was composed of significantly small lumen, thin tube wall and dilated blood vessels which were surrounded by eosinophilic circular or fusiform tumor cells, and the tumor matrix was loose, edema and mucus like, and nuclear fission was rare. All the 10 patients underwent partial complete resection. 8 cases were followed up and the median follow-up time was 37 months. No recurrence occurred. Conclusions：There is no specificity in the clinical manifestation and imaging of AMF which occurs in female genital organs. The diagnosis and differential diagnosis mainly depends on the pathological features and immunohistochemistry. The surgical treatment is the main treatment and the prognosis is good.