卵巢反应性指标的临床研究进展

卵巢反应性是指在控制性卵巢刺激（controlled ovarian stimulation，COS）过程中卵泡对外源性促性腺激素的反应。在辅助生殖技术中，COS是重点亦是难点，因此临床上可以借助一些卵巢反应性评估指标来评估患者在COS过程中的反应性，并选择适合患者的最佳个体化方案，从而在体外受精/胞浆内单精子注射-胚胎移植（in-vitro fertilization/intra-cytoplasmic sperm injection -embryo transfer，IVF/ICSI-ET）中获得理想的妊娠结局。现选取年龄、基础卵泡刺激素、基础卵泡刺激素/基础黄体生成素比值、基础雌二醇、抑制素B、抗苗勒管激素、卵泡输出率和基础窦卵泡数这些常见的卵巢反应性评估指标，就目前国内外的研究现状，总结其评估卵巢反应性及IVF结局的能力，分析不同指标在临床中应用的优越性及局限性，并对评估卵巢反应性的指标进行展望。

Clinical Research Progress of Ovarian Response Predictors

Ovarian response refers to the response of the follicle to the exogenous gonadotropin during the controlled ovarian stimulation (COS). In assisted reproductive technology, COS is the key and difficult step. In clinic, some parameters were used as the predictors of ovarian response during COS, and as the reference of the optimized schedule and individual treatment so as to obtain an ideal outcome of in vitro fertilization/intra-cytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). Some of common ovarian response predictors were evaluated in this review, such as age, basal follicle stimulating hormone (FSH), basal FSH/basal LH ratio, basal estradiol, inhibin B, anti-Mullerian hormone (AMH), follicular output rate and the antral follicle count, in which the evaluation mainly included the ovarian responsiveness and the outcome of IVF/ICSI-ET, as well as their advantages and limitations in clinical application. Meanwhile, the future development of those ovarian response predictors was also proposed.