体外受精-胚胎移植术后未妊娠患者生育压力与生活质量相关性研究

目的：探讨体外受精-胚胎移植（IVF-ET）术后未妊娠患者的生育压力与其生活质量的关系。方法：采用患者基本情况调查表、生育压力量表（FPI量表）和生活质量量表（FertiQoL量表）对北京大学第三医院2017年5-10月在生殖医学中心门诊就诊的351例IVF-ET术后未妊娠患者进行横断面调查，其中移植次数≥3次未妊娠患者为104例、移植次数＜3次未妊娠患者为247例，描述接受IVF-ET术后未妊娠患者生育压力和生活质量的现状，评价其生育压力、生活质量，探讨两者的相互关系。结果：IVF-ET术后未妊娠患者FPI总分为（162.22±20.63）分，FertiQoL总分为（58.79±12.79）分。移植次数≥3次未妊娠患者与移植次数＜3次未妊娠患者FPI总分和各分项得分、FertiQoL总分和各分项得分比较，差异均无统计学意义（均P＞0.05）。Pearson相关分析结果显示，IVF-ET术后未妊娠患者FPI中无子女压力得分与FertiQoL总分呈正相关（P＜0.05），FPI其他项目得分与FertiQoL总分呈负相关（均P＜0.05）。多重线性回归结果显示，生育压力、年龄和文化程度是IVF-ET术后未妊娠患者生活质量的重要影响因素（F=9.140，R2=0.391，P＜0.01）。结论：IVF-ET术后未妊娠患者的生育压力是其生活质量重要的影响因素，其生育压力越大，生活质量越低，应重视移植后未妊娠给患者造成的心理压力，采取积极有效的措施，提高IVF-ET移植后未妊娠患者的生活质量。

The Relationship between Fertility Stress and Life Quality in Non-Pregnant Patients after IVF-ET

Objective：To investigate the relationship between fertility stress and life quality in non-pregnant patients undergoing IVF-ET. Methods：The cross-sectional survey was carried out by studying the basic situation, the Fertility Question Inventory (FPI) scale and the Fertility Quality of Life (FertiQoL) scale among 351 non-pregnant patients with IVF-ET failures in our center from May 2017 to October 2017, including 104 non-pregnant patients underwent more than 3 times of transplantation and 247 non-pregnant patients underwent less than 3 times of transplantation. The fertility stress and life quality was described by FPI and FertiQoL, respectively. The correlation between fertility stress and life quality was explored using Pearson method. Results：The total score of FPI in non-pregnant patients underwent IVF-ET was 162.22±20.63, and the total score of FertiQoL was 58.79±12.79. There were no significant differences in the FPI total scores and sub-item score, and FertiQoL total score and sub-item score, between patients being transplanted more than 3 times and patients being transplanted less than 3 times (all P＞0.05). Pearson analysis showed that there was positive correlation between the childless stress score in FPI and the total score in FertiQoL (P＜0.05), and that there was negative correlation between other item score in FPI and the total score in FertiQoL (P＜0.05). Multiple linear regression analysis showed that fertility stress, age and literacy were the main factors of the life quality in patients with IVF-ET failures (F=9.140, R2=0.391, P＜0.01). Conclusions：The fertility stress of non-pregnant patients underwent IVF-ET is an important factor influencing the life quality. The greater the fertility stress, the lower the life quality. Should pay attention to the psychological pressure in those non-pregnant patients underwent IVF-ET failures, and improve their life quality by proactively releasing the fertility stress.