PI3K/AKT信号通路与前列腺癌关系的研究进展

近年来针对前列腺癌靶向治疗的研究作为新的热点受到越来越多的关注,主要集中在非AR途径的通路及靶点的探索,其中较为成熟且具有明显研究价值的途径之一是磷脂酰肌3-羟激酶(PI3K)/丝氨酸-苏氨酸蛋白激酶(AKT)信号通路。研究表明,该信号通路的异常活化与疾病的发展和转归有显著相关性,在机体细胞的生长、增殖、凋亡以及炎症反应、血管生成以及肿瘤的发生发展中都起到了重要的参与调节作用,所以基于PI3K/AKT信号通路的分子靶向治疗成为治疗前列腺癌潜在的治疗途径。全文就PI3K/AKT信号通路中相关因子的表达,及该信号通路异常活化在前列腺癌发生发展中所产生的影响作用等进行综述。

Research Progress on Relationship between PI3K/AKT Signaling Pathway and Prostate Cancer

In recent years,studies on targeted therapy of prostate cancer as a new hot spot have received more and more attention,and the androgen receptor(AR)pathways and potential targets have been the research focus.As a non-AR pathway,the phosphatidyl muscle,3-hydroxyl kinase(PI3K)/serine and threonine protein kinase(AKT)signaling pathway shows strong potential,which is significantly associated with the development and outcome of prostate cancer,involving in regulation of cell proliferation,apoptosis,inflammation,angiogenesis and tumor progression.Therefore,molecular targeted therapy based on PI3K/AKT signaling pathway would become a novel approach for prostate cancer.This article reviews the expression of related factors on PI3K/AKT signaling pathway and its abnormal activation in prostate cancer progression.