儿童癫痫患者中丙戊酸血药浓度监测的意义及影响因素分析

目的 研究丙戊酸在儿童癫痫患者中的血药浓度监测的意义和临床疗效的影响因素,旨在帮助儿童患者获得有效的血药浓度和满意的临床有效率提供依据.方法 选取2019年6月—2020年3月监测丙戊酸血药浓度的106例15岁及以下的癫痫患者,对其血药浓度监测结果进行分析,并对性别、年龄、每日单位体质量给药剂量、剂型和联合用药等因素对...

Significance of blood drug concentration monitoring of valproic acid in children with epilepsy and analysis of influencing factors

Objective To study the significance of blood concentration monitoring of valproic acid in children with epilepsy and the influencing factors of clinical efficacy, in order to help children obtain effective blood concentration and satisfactory clinical effectiveness. Methods A total of 106 epilepsy patients aged 15 and under who monitored the blood concentration of valproic acid from June 2019 to March 2020 were selected. The monitoring results of their blood concentration were analyzed, and the gender, age, and dose(mg/(kg·d)), the dosage form and the combination of drugs and other factors have a statistical analysis on the influence of blood concentration and clinical efficacy. Results There is a positive correlation between the administered dose and the blood concentration(P < 0.01). The effect of age and drug formulation on blood drug concentration is statistically significant(P < 0.05). The effect of children’s age(3—6 years old group and 7—15 years old group), blood drug concentration, dose, taking sodium valproate sustained-release tablets on the clinical efficacy is statistically significant(P < 0.05). Conclusion The monitoring of blood concentration of valproic acid is an important indicator for evaluating and predicting clinical efficacy. The influencing factors of blood concentration are complicated. There is a significant positive correlation between the dose and the blood concentration of valproic acid. Age and dosage form have a significant effect on valproic acid. The influence of blood drug concentration is of clinical significance;age ≥ 3 years, blood drug concentration, dosage and taking valproic acid sustained-release tablets are independent factors influencing the clinical efficacy of drugs.