LRRK2 G2019S mutation in Parkinson's disease: a neuropsychological and neuropsychiatric study in a large Algerian cohort |
| |
Authors: | Belarbi Soreya Hecham Nassima Lesage Suzanne Kediha Mohamed I Smail Nourredine Benhassine Traki Ysmail-Dahlouk Farida Lohman Ebba Benhabyles Badia Hamadouche Tarik Assami Salima Brice Alexis Tazir Meriem |
| |
Institution: | a Laboratoire de Recherche en Neurosciences, Service de Neurologie, CHU Mustapha, Place du 1er Mai, Algiers 16000, Algeria;b INSERM UMR_S975 (formerly UMR_S679), Department of Genetics, Cytogenetics and Embryology, Pitié- Salpetrière Hospital, Paris, France;c Department of Epidemiology, CHU Mustapha, Algiers, Algeria;d Genetics Laboratory, FSB, Université Bab Ezzouar, Algiers, Algeria;e Molecular Biology Laboratory, Université M’hamed Bougara, Boumerdes, Algeria |
| |
Abstract: | A series of 106 patients with isolated or familial Parkinsonism underwent clinical evaluation and genetic testing for the LRRK2 G2019S mutation which was identified in 34/106 patients (32%). Seventy one of them accepted to be evaluated for neuropsychological and neuropsychiatric studies with the aim to compare mutation carriers with non-carriers. For neuropsychological testing, comparisons between LRRK2 G2019S carriers and non-carriers were made after stratification according to the level of education: median and high school versus low level. Memory was investigated with the five words test, 2 novel tests with verbalized visual material dedicated to illiterate patients, the TNI-93 (nine pictures test), The TMA-93 (associative memory test), and digit spans (forward/backward). Cognitive analyse did not show major differences between the two groups of patients. Nevertheless, behavioral abnormalities, mostly depression and hallucinations, were more frequent in the LRRK2 G2019S carriers, suggesting the presence of a greater involvement of the limbic system in these patients. Sleep disorders which were also more common amongst mutation carriers than non-carriers might be related to depression. |
| |
Keywords: | Parkinson disease LRRK2 gene G2019S Neuropsychological study Depression |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|