高效液相色谱法测定血塞通胶囊中人参皂苷Rg_1、Re、Rb_1、Rd及三七皂苷R_1的含量

[目的]建立血塞通胶囊中5种皂苷的含量测定方法。[方法]采用高效液相色谱法对制剂中的人参皂苷Rg1、Re、Rb1、Rd和三七皂苷R1进行定量测定。[结果]人参皂苷Rg1、Re、Rb1、Rd和三七皂苷R1的线性范围均符合要求,5种皂苷样品回收率均合格,RSD在3.00%以内。[结论]所建立的方法简便、快捷,重复性好,可用于该制剂的质量控制。

Determination of Ginsenoside Rg1, Re, Rb1, Rd and Notoginsenoside R1 in Xuesaitong capsule by HPLC

[Objective] To establish a method for the determination of 5 effective components in Xuesaitong capsule. [Methods] The contents of ginsenoside Rg₁, Re, Rb₁, Rd and notoginsenoside R₁ in Xuesaitong capsule were determined by HPLC. [Results] The resolutions of the determined peaks were fine. The linearity ranges for ginsenoside Rg₁, Re, Rb₁, Rd and notoginsenoside R₁ all met the requirement. The average recoveries of Rg₁, Re, Rb₁, Rb and Notoginsenoside R₁ were qualified, and RSD was less than 3.00% . [Conclusion] The quantitative method for determining the ingredients of Xuesaitong capsule is simple, feasible and repeatable, and is beneficial to quality control of Xuesaitong capsule.