| Transcutol P对痛宁凝胶中延胡索乙素在大鼠体内的药代动力学影响 |
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| 引用本文： | 庞晓晨,刘志东,郭秀君,郭丽丽,尹忠鹏,张倩,萧伟.Transcutol P对痛宁凝胶中延胡索乙素在大鼠体内的药代动力学影响[J].天津中医药,2014,31(6):365-369. |
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| 作者姓名： | 庞晓晨 刘志东 郭秀君 郭丽丽 尹忠鹏 张倩 萧伟 |
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| 作者单位： | 天津中医药大学, 天津市现代中药重点实验室制剂室-省部共建国家重点实验室培育基地, 天津300193;现代中药发现与制剂技术教育部工程研究中心, 天津300193;天津中医药大学, 天津市现代中药重点实验室制剂室-省部共建国家重点实验室培育基地, 天津300193;现代中药发现与制剂技术教育部工程研究中心, 天津300193;天津中医药大学, 天津市现代中药重点实验室制剂室-省部共建国家重点实验室培育基地, 天津300193;现代中药发现与制剂技术教育部工程研究中心, 天津300193;天津中医药大学, 天津市现代中药重点实验室制剂室-省部共建国家重点实验室培育基地, 天津300193;现代中药发现与制剂技术教育部工程研究中心, 天津300193;天津中医药大学, 天津市现代中药重点实验室制剂室-省部共建国家重点实验室培育基地, 天津300193;现代中药发现与制剂技术教育部工程研究中心, 天津300193;天津中医药大学, 天津市现代中药重点实验室制剂室-省部共建国家重点实验室培育基地, 天津300193;现代中药发现与制剂技术教育部工程研究中心, 天津300193;江苏康缘药业股份有限公司, 连云港222001;中药制药过程新技术国家重点实验室, 连云港222001 |
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| 基金项目： | 国家重点实验室开放基金项目（SKL2010M0301）。 |
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| 摘 要： | 目的]建立一种快速灵敏的超高效液相色谱-串联质谱(UPLC-MS/MS)方法测定大鼠血浆中延胡索乙素含量,研究含7%单乙基二甘醇油醚(Trans P)的痛宁凝胶在大鼠体内的药代动力学过程,考察其透皮吸收促进效果。方法]采用血药浓度法,UPLC-MS/MS测定大鼠体内痛宁凝胶中延胡索乙素含量,同时与空白痛宁凝胶体内药代动力学参数进行比较。结果]7%Trans P组的Tmax、Cmax与空白对照组相比差异具有显著性(P0.05),药时曲线下面积AUC(0→24 h)和AUC(0→∞)与空白对照组相比差异具有显著性(P0.05)。结论]应用UPLC-MS/MS技术测定痛宁凝胶中延胡索乙素的血药浓度,药代动力学参数表明7%Trans P组促渗效果明显优于空白对照组,可进一步应用于痛宁凝胶制剂中。
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| 关 键 词： | 延胡索乙素|痛宁凝胶|UPLC-MS/MS|药代动力学 |
| 收稿时间： | 1/5/2014 12:00:00 AM |
Effects of Transcutol P on pharmacokinetics of Tetrahydropulmatine in Tongning gel in rats |
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| PANG Xiao-chen,LIU Zhi-dong,GUO Xiu-jun,GUO Li-li,YIN Zhong-peng,ZHANG Qian and Xiao Wei.Effects of Transcutol P on pharmacokinetics of Tetrahydropulmatine in Tongning gel in rats[J].Tianjin Journal of Traditional Chin Medicine,2014,31(6):365-369. |
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| Authors: | PANG Xiao-chen LIU Zhi-dong GUO Xiu-jun GUO Li-li YIN Zhong-peng ZHANG Qian and Xiao Wei |
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| Institution: | Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China;Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China;Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China;Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China;Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China;Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China;Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China;Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China;Jiangsu Kanion Pharmaceut Co. Ltd. , Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China |
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| Abstract: | |
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| Keywords: | Tetrahydropulmatine|Tongning gel|UPLC-MS/MS|pharmacokinetics |
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