| 知母水、醇提取液的急性毒性实验研究 |
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| 引用本文： | 刘芳,李兰芳,刘广杰,姜红,张勤增. 知母水、醇提取液的急性毒性实验研究[J]. 天津中医药, 2014, 31(6): 361-364 |
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| 作者姓名： | 刘芳 李兰芳 刘广杰 姜红 张勤增 |
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| 作者单位： | 河北医科大学第四医院胸二科, 石家庄050011;河北省疾病预防控制中心药研所, 石家庄050021;河北医科大学第四医院胸二科, 石家庄050011;河北省疾病预防控制中心药研所, 石家庄050021;河北省疾病预防控制中心药研所, 石家庄050021 |
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| 基金项目： | 河北省中医药管理局资助项目（2012015）。 |
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| 摘 要： | [目的]观察知母水、醇提取液的急性毒性反应。[方法]选择昆明种小鼠为受试对象,采用急性经口毒性实验测定知母水、醇提取液的的最大耐受量。[结果]知母水提液的小鼠经口最大耐受量为35.0g/kg。知母80%乙醇提取液的小鼠经口最大耐受量为37.5 g/kg。[结论]知母水、醇提取液的毒性较低,临床给药安全可靠。
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| 关 键 词： | 知母|急性毒性|最大耐受量 |
| 收稿时间： | 2013-12-27 |
Study on acute toxicity of water and alcohol extract of Anemarrhenae Rhizoma |
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| LIU Fang,LI Lan-fang,LIU Guang-jie,JIANG Hong and ZHANG Qin-zeng. Study on acute toxicity of water and alcohol extract of Anemarrhenae Rhizoma[J]. Tianjin Journal of Traditional Chin Medicine, 2014, 31(6): 361-364 |
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| Authors: | LIU Fang LI Lan-fang LIU Guang-jie JIANG Hong ZHANG Qin-zeng |
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| Affiliation: | Department of Second Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;Chinese Center for Disease Control and Prevention in Hebei Province, Shijiazhuang 050021, China;Department of Second Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;Chinese Center for Disease Control and Prevention in Hebei Province, Shijiazhuang 050021, China;Chinese Center for Disease Control and Prevention in Hebei Province, Shijiazhuang 050021, China |
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| Abstract: | [Objective] To observe the acute toxicity of water and alcohol extract of Anemarrhenae Rhizoma. [Methods] Kunming mice were used to test the maximum tolerated dose of water and alcohol extract of Anemarrhenae Rhizoma. [Results] The maximum tolerated dose of water extract of Anemarrhenae Rhizoma was 35.0 g/kg and the maximum tolerated dose of 80%alcohol extract of Anemarrhenae Rhizoma was 37.5 g/kg. [Conclusion] The water and alcohol extract of Anemarrhenae Rhizoma is safe for clinical administration. |
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| Keywords: | Anemarrhenae Rhizoma|acute toxity|maximum tolerated dose |
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