重组人生长激素对严重烧伤后机体代谢的影响

目的　探讨重组人生长激素 (rhGH)对严重烧伤患者代谢的影响。　方法　烧伤患者2 4例 ,随机分为rhGH治疗组和对照组 ,每组 12例。分别于伤后第 3～ 17天皮下注射rhGH(9U/d)和等量等渗盐水。于伤后第 3、10、17天抽血检测血清生长激素 (GH)、胰岛素样生长因子 (IGF 1)、胰岛素样生长因子结合蛋白 3(IGFBP 3)、血清蛋白、血浆胰岛素、血浆胰高血糖素及血糖值 ,进行对比分析。　结果　伤后第 10、17天 ,rhGH治疗组血清GH、IGF 1、IGFBP 3、血清前白蛋白及转铁蛋白值均明显高于对照组 (P <0 .0 5～ 0 .0 1) ,两组各时相点血清白蛋白、血浆胰岛素、胰高血糖素及血糖浓度比较差异无显著性意义 (P >0 .0 5 )。　结论　严重烧伤后应用小剂量rhGH能促进机体蛋白质合成 ,对血糖无影响

The influence of recombinant human growth hormones on the systemic metabolism after severe burn

OBJECTIVE: To explore the influence of recombinant human growth hormones (rhGH) postburn systemic metabolism. METHODS: Twenty-four burn patients were randomly and equally divided into treatment and control groups. Same amount of rhGH (9 U/d) or isotonic saline was injected subcutaneously to respective patients during 3 approximately 17 postburn days (PBDs). Blood samples were harvested at 3, 10 and 17 PBDs for the determination of serum growth hormone, insulin-like growth factor (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), serum proteins, plasma insulin, plasma glucagons and blood glucose, which were then compared and analyzed between two the groups. RESULTS: The serum levels of GH, IGF-1, IGFBP-3, serum prealbumin and transferrin in rhGH treatment group were evidently higher than those in control groups at 10 and 17 PBDs (P < 0.05 approximately 0.01). But there was no obvious difference in serum albumin, plasma insulin, glucagon and blood glucose (P > 0.05). CONCLUSION: Small dose of rhGH could promote systemic protein synthesis with no side effects on blood glucose levels.