川芎嗪注射液对失血性休克大鼠转归时淋巴循环的干预作用

目的:探讨川芎嗪注射液对失血性休克转归时淋巴循环的干预作用。方法:W istar雄性大鼠16只,分成实验组和对照组两组,采用淋巴学研究方法,观察川芎嗪对失血性休克大鼠肠淋巴循环的干预作用。结果:在失血性休克时,肠淋巴流量、淋巴细胞输出量明显降低,淋巴液中有少量单核细胞,且淋巴液粘度较高。经川芎嗪治疗后,肠淋巴流量、淋巴细胞输出量显著增加,淋巴液中单核细胞明显增多,与对照组比较有显著性差异(P<0.01)。此外,川芎嗪可明显降低淋巴液粘度,其作用明显强于对照治疗组(P<0.01)。结论:川芎嗪能通过增强淋巴管转运功能、增加淋巴液细胞总数和单核细胞数目、降低淋巴液粘度作用,影响失血性休克的转归。

Interferential Effect of Ligustrazine Injection on Lymph Circulation During the Recovery of Hemorrhagic Shock in Rats

Objective: To explore effects of ligustrazine injection (LI) on lymph circulation during the recovery of heamoregic shock.Methods: Effects of LI on lymph circulation were observed and determined in 16 Wistar rats by lymphatology methods.Results: During hemorrhagic shock,the intestinal lymph flux,lymphocytes out put was obviously decreased,and there was little monocytes in the lymph fluid,but the lymph fluid viscosity was increased.After treatment of LI,the intestinal lymph flux,lymphocytes out put was obviously increased, and there was a lot of monocytes in the lymph fluid.There were significant difference compared with control group(P<0.01).Besides,LI could make the lymph fluid viscosity decrease and the effect was strong than that of control group((P<0.01).) Conclusion: LI can intervene the recovery of heamoregic shock through enhaning the transport function of lymph circulation,the number of lymphocytes and monocytes,and decreasing lymph fluid viscosity.