LYVE-1在胃癌中的表达及意义

目的：通过LYVE-1在胃癌组织中的表达,探讨胃癌组织癌内、癌周淋巴管生成机制及其与淋巴结转移的关系。方法：选用泸州医学院附属医院病理科随访的53例胃癌患者的手术切除组织病理存档蜡块,利用免疫组织化学方法检测LYVE-1和nm23在53例胃癌组织及正常胃黏膜组织中的表达,并进行微淋巴管密度（lymphatic vessel density,MLD）计数;分析nm23表达与LYVE-1阳性MLD、淋巴结转移的关系。结果：在胃癌组织中,癌周LYVE-1阳性MLD在淋巴结转移阳性组明显高于淋巴结转移阴性组（P〈0.01）;并显著高于正常胃黏膜组织及癌内组织（P〈0.01）;后两者MLD无显著性差异（P〉0.05）。而癌内LYVE-1阳性MLD在各临床病理参数之间无显著差别（P〉0.05）。结论：癌周淋巴管生成可能促进了淋巴结转移的发生,癌周淋巴管对胃癌的发生、发展起重要作用。

EXPRESSION AND SIGNIFICANCE OF LYVE-1 IN GASTRIC CARCINOMA

Objective：To study the expression of LYVE-1 in gastric carcinoma and its role in intra-and peritumoral lymphangiogenesis and lymph node metastasis.Methods： The expressions of LYVE-1 and nm23 in 53 paraffin sections of gastric carcinoma were studied using immunohistochemistry.Micro-lymphatic vessel density（MLD） was also measured.Results： LYVE-1 positive MLD in peritumoral regions of gastric carcinoma tissues and in lymph node metastasis was significantly higher than that in normal tissue and without lymph node metastasis（P﹤0.01）.No significant differences between MLD in normal tissues and in intratumoral regions was observed（P﹥0.05）.Conclusions： It is suggested that peritumoral lymphangiogenesis might promote lymph node metastasis.Peritumoral lymphangiogenesis may play an important role in the onset and progression of gastric carcinoma.