国产拉西地平对广西轻中度原发性高血压50例患者24h动态血压的影响

目的探讨拉西地平（司乐平）对广西轻中度原发性高血压的降压疗效。方法选50例轻中度原发性高血压患者采用自身对照开放法，停用原来降压药物2周后随诊血压（CBP）仍≥160／95mmHg（1mmHg=0．133kPa）者口服拉西地平4—8mg／d共4周，期间不服用其他降压药。结果治疗4周后随诊血压（CBP）降低总有效率为88％，动态血压曲线明显降低，谷峰比值收缩压为65．2％，舒张压为61．1％。结论国产拉西地平4—8mg／d对轻中度原发性高血压患者具有安全有效的降压作用，耐受性好，不良反应少。

The effect of domestic lacidipine on 24-hour ambulatory blood pressure in 50 patients with essential hypertention

Objective To explore the therapeutic effect of laeidipine in the treatment of patients with mild to moderate hypertention. Methods By the open self-control method, 50 patients with casual blood pressure （CBP） ≥ 160/95 mmHg sifter 2 weeks of stopping antihypertensive drugs, received lacidipine 4 - 8 mg daily for 4 weeks without any other antihypertensive drugs. The 24 h ambulatory blood pressure monitoring （ABPm） and CBP were obsered. Results After 4 weeks of treatment CBP reduced, the total effective rate was 88%, the curve of ABPm descended after treatment, the trough-peak ratio of systolic blood pressure was 65.2%, the trough-peak ratio of diastolic blood pressure was 61.1%. Conclusion Doses of 4 -8 mg/d domestic lacidipine have a safe and effective effect in the treatment of patients with mild to moderate hypertention with better tolerance and less adverse reactions. Lacidiple is a safe and effective antihypertensive drug.