地诺前列酮用于足月妊娠促宫颈成熟及引产的临床效果及安全性分析

目的探讨地诺前列酮（普贝生）用于足月妊娠促宫颈成熟及引产的效果及安全性。方法采用随机对照前瞻陛研究的方法，将90例足月妊娠宫颈Bishop评分3～5分，有引产指征，无前列腺素使用禁忌证的足月单活胎头位孕妇随机分为两组：普贝生组（n=45）患者在阴道后穹窿放置普贝生；缩宫素组（n=45）患者静脉输注缩宫素。结果用药12h后，普贝生组宫颈成熟度明显优于缩宫素组，平均临产时间、破膜时间、分娩时间均较缩宫素组明显缩短，引产成功率达77．78％，明显高于缩宫素组的33．33％。结论普贝生是一种安全有效的促宫颈成熟和引产药物，值得临床推广。

Clinical analysis of dinoprostone for cervical ripening and inducing labor in full term pregnancies

Objective To investigate the efficacy and safety of dinoprostone for cervical ripening and inducing labor in full term pregnancies. Methods In the prospective, randomized, controlled study, ninety pregnant women with single cephalic term pregnancies （ Bishop score 3～5） were divided randomly into dinoprostone group （ n = 45, treated with dinoprostone） and oxytocin group （n = 45, treated with oxytocin）. Results The Bishop score in the dinoprostone group was significantly higher and the parturient time, time of ruptured membranes, labor duration were significantly shorter than those in the oxytocin group at 12 h after treatment. The success rate of labor induction was 77.78% in the dinoprostone group, which was significantly higher than 33. 33% in the oxytocin group. Conclusion Dinoprostone is a safe and effective agent for cervical ripening and inducing labor, and worthy of spreading in clinical practice.