口服小剂量红霉素治疗早产儿喂养不耐受28例的临床疗效观察

目的观察口服小剂量红霉素治疗早产儿喂养不耐受的临床疗效与安全性。方法将56例喂养不耐受需经鼻胃管喂养的早产儿随机分为两组，每组28例，两组均采用相同的早产儿配方奶经鼻胃管喂养和静脉营养，治疗组在此基础上应用口服小剂量红霉素（3～5mg／kg^-1·d^-1）治疗。结果治疗组的疗效和总有效率均优于对照组（P〈0．01）。结论口服小剂量红霉素治疗早产儿喂养不耐受具有疗效确切，给药方便，且剂量小，疗程短，无明显不良反应等优点，值得临床推广使用。

Observation of therapentic effect of small dose oral erythromycin in the treatment of premature infants withfeeding intolerance.

Objective To observe the clinical therapeutic effect and safety of small dose oral evythromycin in the treatment of premature infants with feeding intolerance. Methods Fifty-six premature infants with feeding intolerance who needed feeding by nasogastric tube hospitalized in our newborn ward were randomly divided into two groups ：the treatment growp（n =28） and the control growp（n =28）. The premature infants in both groups were fed with the same premature infants formula milk by nasogastric tube and received parenteral nutrition. On the basis of above treatment, The premature infants in the treatment gronp were treated with small dose oral erythromycin （3 -5 mg/ kg^-1 · d^-1 ）. Results The treatment group was superior to the control group in the therapeutic effect and the total effective rate （ all P 〈 0. 01 ）. Conclusion Small dose oral erythromycin in the treatment of premature infants with feeding intolerance has the advantages of exact therapeutic effect, convenient administration, small dose, short course of treatment,no obvious side effects,and so on, and is worthy of promotion and application in clinics.