| 增殖细胞核抗原在卵巢上皮性癌的表达及其临床意义 |
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| 引用本文： | 李俊东,李孟达,张昌卿,李艳芳,刘富元,刘继红,冯凯涛. 增殖细胞核抗原在卵巢上皮性癌的表达及其临床意义[J]. 癌症, 2000, 19(3): 265-267,270 |
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| 作者姓名： | 李俊东 李孟达 张昌卿 李艳芳 刘富元 刘继红 冯凯涛 |
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| 作者单位： | 1. 中山医科大学肿瘤防治中心妇科,广东广州510060
2. 中山医科大学肿瘤防治中心中心实验室,广东广州510060 |
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| 摘 要： | 探讨增殖细胞核抗原表达与卵巢上皮性癌生物学行为及预后的关系。材料与方法：采用ＬＳＡＢ免疫组化方法检测８４例石蜡包埋的卵巢上皮性癌组织中增殖细胞核抗原的表达，分析其与患者的年龄、临床分期、组织分化程度、组织学类型及预后之间的关系。
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| 关 键 词： | 卵巢肿瘤 增殖细胞抗原 卵巢上皮性癌 |
| 文章编号： | 1000－467X(2000)03－0265－03 |
Expression and clinical significance of proliferating cell nuclear antigen in patients with ovarian epithelial carcinoma |
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| LI Jundong,LI Mengda,ZHANG Changqing,et al. Expression and clinical significance of proliferating cell nuclear antigen in patients with ovarian epithelial carcinoma[J]. Chinese journal of cancer, 2000, 19(3): 265-267,270 |
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| Authors: | LI Jundong LI Mengda ZHANG Changqing et al |
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| Affiliation: | LI Jundong,LI Mengda,ZHANG Changqing,et al Department of Gynecologic Oncology,Cancer Center,Sun Yatsen University of Medical Sciences,Guangzhou 510060,PRChina |
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| Abstract: | Objective:To investigate the relationship between the expressions of proliferating cell nuclear antigen (PCNA) and the clinicobiological characteristics and prognosis in ovarian epithelial carcinomaMethods:84 specimens of ovarian epithelial carcinoma were detected for the expressions of PCNA by using labellingstreptavidinbiotin(LSAB) immunohistochemistry assay, and the correlations were analyzed for the PCNA expression with stage, histological grade, and histologic subtype of the tumor, and age and prgnosis ofthe patientResults:All tumors had PCNA expression, the positive rate was 100%There were significant correlations between the expressional grade of PCNA and the age (P< 005 ), and histological grade ( P< 001 )No significant correlation was found between the expressional grade of PCNA and stage or histologic subtype ( P > 005 )In unvariate analysis, the expression of PCNA was associated with poor survival in ovarian epithelial carcinoma, but it did not retainany prognostic significance in multivariate analysisConclusions:PCNA expressions in ovarian epithelial carcinoma is high The tumor with lower histological grade, or in the patients of older age, will express higher level of PCNAThe expression of PCNA is not an independent prognostic factor for prognosis in epithelial ovarian carcinomaStage and histological grade are still the significant prognostic factors in the epithelial ovarian cancer |
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| Keywords: | Ovarian neoplasma PCNA Clinicobiology Prognosis |
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