| 多糖单克隆抗体的研究进展 |
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| 引用本文： | 谢陶吟,赵虎,高向东.多糖单克隆抗体的研究进展[J].药学进展,2005,29(9):391-397. |
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| 作者姓名： | 谢陶吟 赵虎 高向东 |
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| 作者单位： | 中国药科大学生命科学与技术学院,江苏,南京,210009 |
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| 基金项目： | 国家自然科学基金资助项目(30472061) |
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| 摘 要： | 介绍了制备多糖抗原的两种方法及影响多糖免疫原性的因素,并综述了检测多糖单抗的酶联免疫吸附测定法的最新进展以及多糖单克隆抗体在菌体亚型分类、抗原表位研究、疾病诊断治疗和多糖药代动力学研究等方面的应用情况。
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| 关 键 词： | 多糖 单克隆抗体 偶联物 拟糖肽 |
| 文章编号： | 1001-5094（2005）09-0391-07 |
| 收稿时间： | 2005-03-09 |
| 修稿时间： | 2005年3月9日 |
Advances in the Research on the Monoclonal Antibody against Polysaccharides |
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| XIE Tao-yin,ZHAO Hu,GAO Xiang-dong.Advances in the Research on the Monoclonal Antibody against Polysaccharides[J].Progress in Pharmaceutical Sciences,2005,29(9):391-397. |
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| Authors: | XIE Tao-yin ZHAO Hu GAO Xiang-dong |
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| Abstract: | Two methods of preparing the antigen and the factors affecting immunogenicity of polysaccharides were indroduced. The recent development of ELISA for monoclonal antibodies against polysaccharides and the applications of monoclonal antibodies against polysaccharides, including the classification of subgroup, the studies of epitope, the diagnosis and treatment of infection and disease, and the developing pharmacokinetics of polysaccharides were also reviewed. |
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| Keywords: | Polysaccharides Monoclonal antibody Conjugation Peptide mimotope |
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