Controlled trial of protease inhibitor gabexelate mesilate (FOY) in the treatment of acute pancreatitis |
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| Authors: | C Y Yang C S Chang-Chien Y F Liaw |
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| Institution: | Department of Gastroenterology, Chang Gung Memorial Hospital, Lin Kou Medical Center, Taiwan, Republic of China. |
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| Abstract: | A controlled trial with synthetic protease inhibitor gabexelate mesilate (FOY) in the treatment of acute pancreatitis was conducted in a total of 42 patients. The age, sex, etiology of pancreatitis, initial serum amylase level, and amylase creatinine clearance ratio were comparable between FOY-treated and control groups. FOY did not alter the course of the disease, but there was a weak trend toward lower morbidity and mortality in the FOY-treated patients. These results may justify further, larger scale studies or evaluation of alternate dosage or route of administration. |
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