氯氮平与其他抗精神病药物致粒细胞缺乏对照研究的Meta分析

为进一步认识氯氮平与其他抗精神病药物致粒细胞缺乏的差异,按标准对收集的、关于氯氮平与其他抗精神病药致粒细胞缺乏的对照研究论文结果作Meta分析。结果:(1)氯氮平与其他抗精神病药物导致粒细胞缺乏有非常显著性差异(X~2=11.20,df=1,P<0.01);(2)氯氮平引起粒细胞缺乏的危验性是其他抗精神病药物的8.8倍(OR=8.8);(3)病因学分数:EF_(暴露)因素=0.88,即氯氮平治疗组中出现粒缺者,88％是由氯氮平引起的,EF_(总体)=0.88,即在全部被治疗的精神分裂症出现粒缺者,88％由氯氮平引起。提示,氯氮平引起粒细胞缺乏效应显著高于其他抗精神病药物。

Meta Analysis of Control Study of Agranulocytosis by Clozapine or Other Antipsychotics

to further understand the difference of agranulocytosis by clozapine or other antipsychotics. Meta analyses were made for the results of control study's article about agranulocytosis by clozapine or other antipsychotics. Results: (1)there was significant difference in agranulotics(P<0. 01) ; (2)the agranulotosis risk by clozapine was 8. 8 times as high as by others(or=8. 8);(3)etiology fraction:EFexposure factor=0. 88, i. e. among the patients in clozapine group, 88 % was caused by clozapine; EFtotal = 0. 88,i. e. among all the treated patients, 88 % was caused by clozapine. These suggeted that agranulocytosis effect by clozapine was significantly higher than that by other antipsychotics.