乳腺癌组织中环氧化酶-2的表达及其意义

目的 :观察环氧化酶 -2 (cyclooxy genase 2 ,COX 2 )在乳腺癌中的表达 ,并探讨其临床病理意义。方法 :采用免疫组织化学方法检测了 80例乳腺癌、2 7例乳腺不典型增生以及 2 0例正常乳腺组织中COX 2表达并分析其与临床病理的相关性。结果 :乳腺癌组织中COX 2阳性表达率为 5 7 5 % ( 4 6/80 ) ,明显高于乳腺不典型增生 11 1% ( 3 / 2 7)和正常乳腺组织 10 0 % ( 2 / 2 0 ) ,P <0 0 1。COX 2表达与淋巴结转移、临床分期、组织学分级相关 ,P <0 0 5。COX 2高表达的乳腺癌术后 5年无病生存率明显高于COX 2低表达者 ,P <0 0 5。结论 :COX 2表达可以作为判定乳腺癌恶性程度和预后的有效生物学指标

Expression of COX-2 and its significance in breast cancer

OBJECTIVE:To study the expression of COX-2 and its clinicopathological significance in human breast cancer.METHODS: Archival breast carcinomas (n=80), atypical hyperplasia (n=27) and normal breast epithelia (n=20) were analyzed for COX-2 expression by immunohistochemistry using specific monoclonal antibodies.RESULTS: Fifty-seven point five percent (46/80) of breast carcinomas expressed COX-2 at a moderate to high level, which was significantly different from the expression in the benign and normal breast epithelia. COX-2 expression was correlated with the histological grade, lymphnode metastasis, TNM stage,P<0.05 or P<0.01. The 5- year DFS of the COX-2 negative group was significantly higher than that of the COX-2 positive group in breast cancer,P<0.05. CONCLUSIONS: COX-2 may be a useful marker for reflecting tumor malignant behavior and estimating prognosis of human breast cancer.