| 妊娠期肝内胆汁淤积症患者瘙痒情况与围生儿结局 |
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| 引用本文： | 韩平,邹丽,孙荻娜,汤斐,周萍. 妊娠期肝内胆汁淤积症患者瘙痒情况与围生儿结局[J]. 中国综合临床, 2006, 22(10): 930-932 |
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| 作者姓名： | 韩平 邹丽 孙荻娜 汤斐 周萍 |
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| 作者单位： | 1. 210029,南京,南京医科大学第一附属医院妇产科
2. 华中科技大学同济医学院附属协和医院妇产科 |
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| 摘 要： | 目的探讨妊娠期肝内胆汁淤积症（ICP）患者瘙瘁情况与围生儿结局的关系。方法对84例有完整病史及分娩记录的ICP患者的临床资料进行回顾性分析。结果瘙痒症状发生早、分娩前瘙痒症状持续时间长者中胆汁酸、胆红素同时升高的比例增加，胆汁酸、胆红素值升高；羊水胎粪污染发生率、早产率、新生儿窒息发生率增加，差异有显著性（P〈0．05）。结论ICP患者瘙痒情况与胆汁酸、胆红素的改变及围生儿结局有一定的关系，医、患均需高度重视，早发现、早诊断、早治疗，适时终止妊娠，改善围生儿预后。
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| 关 键 词： | 妊娠期肝内胆汁淤积症 围生儿 |
| 文章编号： | 1008-6315(2006)10-0930-03 |
| 修稿时间： | 2005-12-12 |
Relationship between maternal pruritus and outcome of perinatal-fetus in intrahepatic cholestasis of pregnancy |
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| Han Ping,Zhou Li,Sun Dina,et al.. Relationship between maternal pruritus and outcome of perinatal-fetus in intrahepatic cholestasis of pregnancy[J]. Clinical Medicine of China, 2006, 22(10): 930-932 |
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| Authors: | Han Ping Zhou Li Sun Dina et al. |
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| Affiliation: | Han Ping,Zhou Li,Sun Dina,et al.Department of Obstetrics and Gynecology,First Affiliated Hospital of Nanjing Medical University |
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| Abstract: | Objective To investigate the relationship between maternal pruritus and outcome of perinatal-fetus in intrahepatic cholestasis of pregnancy(ICP).Methods Clinical data of 84 cases with complete history and delivery record were retrospectively analyzed.Results Both bile acid and bilirubin increased in the patients whose pruritus occurred early in pregnancy and persisted for a long time and;the incidence of meconium,premature delivery and asphyxia neonatorum were also increased,with significant difference(P<0.05).Conclusion The pruritus of ICP patients is related to the changes of bile acid and bilirubin as well as the outcome of perinatal-fetus.Early diagnosis and treatment as well as timely termination of pregnancy may improve the prognosis of fetuses. |
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| Keywords: | intrahepatic cholestasis of pregnancy perinatal-fetus |
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