山楂水提物对大鼠离体胃、肠平滑肌条收缩性的影响研究

目的:研究山楂水提物对大鼠离体胃、肠平滑肌条收缩性的影响。方法:以大鼠离体胃、肠平滑肌条为研究对象,观察在正常克氏液条件下加入山楂水提物后大鼠胃、肠平滑肌条的收缩状况及在乙酰胆碱、阿托品作用下加入山楂水提物后大鼠肠平滑肌条的收缩状况。结果:山楂水提物在5～20mg·mL-1浓度范围内可显著增强大鼠胃、肠平滑肌条的运动,且具有显著剂量依赖性。山楂水提物(20mg·mL-1)可加强乙酰胆碱引起的肠平滑肌的强烈收缩,对抗阿托品引起的肠平滑肌的舒张作用。结论:山楂水提物对大鼠胃、肠平滑肌条的收缩具有显著的刺激作用。

Effects of Folium Crataegi Water Extract on the Contractility of Isolated Gastric and Intestinal Muscle Strips in Rats

OBJECTIVE： To study the effects of Folium Crataegi water extract on contractility of isolated gastric and intestinal smooth muscle strips in rats. METHODS： The effects of Folium Crataegi water extract on the contractility of isolated rat gastric and intestinal smooth muscle strips in the presence of normal Krebs＇ solution, acetylcholine or atropine were investigated. RESULTS： Folium Crataegi water extract （5-20 mg. mL^-1） significantly enhanced the contractility of rat gastric and intestinal smooth muscle strips in a dose-dependent manner, and Folium Crataegi water extract （20 mg. mL^-1） could enhance the intensive contraction induced by acetylcholine and antagonize the relaxation of intestinal smooth muscle induced by atropine. CONCLUSION： Folium Crataegi water extract has remarkable stimulation on the contractility of isolated rat gastric and intestinal smooth muscle strips.